methyl 4-[4'-(3''-hydroxy-4''-methyl-4''-phenylsulfanyl-pentanoylamino)-4'-methyl-pentanoylamino]-4-methyl-pentanoate

Base Information

Chemical Name:methyl 4-[4'-(3''-hydroxy-4''-methyl-4''-phenylsulfanyl-pentanoylamino)-4'-methyl-pentanoylamino]-4-methyl-pentanoate
CAS No.:910865-34-8
Molecular Formula:C₂₅H₄₀N₂O₅S
Molecular Weight:480.669
Hs Code.:

Synonyms:methyl 4-[4'-(3''-hydroxy-4''-methyl-4''-phenylsulfanyl-pentanoylamino)-4'-methyl-pentanoylamino]-4-methyl-pentanoate

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Chemical Property of methyl 4-[4'-(3''-hydroxy-4''-methyl-4''-phenylsulfanyl-pentanoylamino)-4'-methyl-pentanoylamino]-4-methyl-pentanoate

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Technology Process of methyl 4-[4'-(3''-hydroxy-4''-methyl-4''-phenylsulfanyl-pentanoylamino)-4'-methyl-pentanoylamino]-4-methyl-pentanoate

There total 11 articles about methyl 4-[4'-(3''-hydroxy-4''-methyl-4''-phenylsulfanyl-pentanoylamino)-4'-methyl-pentanoylamino]-4-methyl-pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 67-56-1
methanol

: 910865-33-7
tert-butyl 4-[4'-(3''-hydroxy-4''-methyl-4''-phenylsulfanyl-pentanoylamino)-4'-methyl-pentanoylamino]-4-methyl-pentanoate

: 910865-34-8
methyl 4-[4'-(3''-hydroxy-4''-methyl-4''-phenylsulfanyl-pentanoylamino)-4'-methyl-pentanoylamino]-4-methyl-pentanoate

Guidance literature:: With hydrogenchloride; at 20 ℃; for 24h;
DOI:10.1039/b606882k

Reference yield:

: 627539-06-4
tert-butyl 4-methyl-4-nitropentanoate

: 910865-34-8
methyl 4-[4'-(3''-hydroxy-4''-methyl-4''-phenylsulfanyl-pentanoylamino)-4'-methyl-pentanoylamino]-4-methyl-pentanoate

Guidance literature:: Multi-step reaction with 7 steps

1: 60 percent / H₂ / Raney nickiel / ethanol

2: 3.60 g / triethylamine / tetrahydrofuran / 20 °C

3: 69 percent / SOCl₂ / 48 h / 40 °C

4: 82 percent / KOH; H₂O / methanol / 20 °C

5: DCC / tetrahydrofuran / 20 °C

6: 1.40 g / triethylamine / tetrahydrofuran / 20 °C

7: 62 percent / aq. HCl / 24 h / 20 °C

With hydrogenchloride; potassium hydroxide; thionyl chloride; water; hydrogen; triethylamine; dicyclohexyl-carbodiimide; Raney nickiel; In tetrahydrofuran; methanol; ethanol;
DOI:10.1039/b606882k

Reference yield:

: 161295-14-3
tert-butyl 4-methyl-4-aminopentanoate

: 910865-34-8
methyl 4-[4'-(3''-hydroxy-4''-methyl-4''-phenylsulfanyl-pentanoylamino)-4'-methyl-pentanoylamino]-4-methyl-pentanoate

Guidance literature:: Multi-step reaction with 6 steps

1: 3.60 g / triethylamine / tetrahydrofuran / 20 °C

2: 69 percent / SOCl₂ / 48 h / 40 °C

3: 82 percent / KOH; H₂O / methanol / 20 °C

4: DCC / tetrahydrofuran / 20 °C

5: 1.40 g / triethylamine / tetrahydrofuran / 20 °C

6: 62 percent / aq. HCl / 24 h / 20 °C

With hydrogenchloride; potassium hydroxide; thionyl chloride; water; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol;
DOI:10.1039/b606882k