N-{(1S)-1-[(benzyloxy)methyl]-2-methylpropyl}-N-{(1E)-phenyl[(2S)-2-phenyl-3,4-dihydropyridin-1(2H)-yl]methylene}amine

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Chemical Name:N-{(1S)-1-[(benzyloxy)methyl]-2-methylpropyl}-N-{(1E)-phenyl[(2S)-2-phenyl-3,4-dihydropyridin-1(2H)-yl]methylene}amine
CAS No.:857899-98-0
Molecular Formula:C₃₀H₃₄N₂O
Molecular Weight:438.613
Hs Code.:

Synonyms:N-{(1S)-1-[(benzyloxy)methyl]-2-methylpropyl}-N-{(1E)-phenyl[(2S)-2-phenyl-3,4-dihydropyridin-1(2H)-yl]methylene}amine

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Chemical Property of N-{(1S)-1-[(benzyloxy)methyl]-2-methylpropyl}-N-{(1E)-phenyl[(2S)-2-phenyl-3,4-dihydropyridin-1(2H)-yl]methylene}amine

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Technology Process of N-{(1S)-1-[(benzyloxy)methyl]-2-methylpropyl}-N-{(1E)-phenyl[(2S)-2-phenyl-3,4-dihydropyridin-1(2H)-yl]methylene}amine

There total 4 articles about N-{(1S)-1-[(benzyloxy)methyl]-2-methylpropyl}-N-{(1E)-phenyl[(2S)-2-phenyl-3,4-dihydropyridin-1(2H)-yl]methylene}amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 857899-97-9
N-{(1S)-1-[(benzyloxy)methyl]-2-methylpropyl}-N-{(1E)-phenyl[(2S)-2-phenylpyridin-1(2H)-yl]methylene}amine

: 857899-98-0
N-{(1S)-1-[(benzyloxy)methyl]-2-methylpropyl}-N-{(1E)-phenyl[(2S)-2-phenyl-3,4-dihydropyridin-1(2H)-yl]methylene}amine

Guidance literature:: With hydrogen; palladium on activated charcoal; In acetonitrile; at 20 ℃; for 2h; under 750.06 Torr;
DOI:10.1021/ol051022z

Reference yield:

: Trifluoro-methanesulfonate1-{[(E)-(S)-1-benzyloxymethyl-2-methyl-propylimino]-phenyl-methyl}-pyridinium;

: 857899-98-0
N-{(1S)-1-[(benzyloxy)methyl]-2-methylpropyl}-N-{(1E)-phenyl[(2S)-2-phenyl-3,4-dihydropyridin-1(2H)-yl]methylene}amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium bromide; magnesium bromide diethyl etherate / diethyl ether / 1 h / 20 °C

1.2: 1.7 g / CH₂Cl₂; diethyl ether / 5.75 h / -30 °C

2.1: 77 percent / hydrogen / Pd/C / acetonitrile / 2 h / 20 °C / 750.06 Torr

With hydrogen; magnesium bromide ethyl etherate; lithium bromide; palladium on activated charcoal; In diethyl ether; acetonitrile;
DOI:10.1021/ol051022z

Reference yield:

: 110-86-1
pyridine

: 857899-98-0
N-{(1S)-1-[(benzyloxy)methyl]-2-methylpropyl}-N-{(1E)-phenyl[(2S)-2-phenyl-3,4-dihydropyridin-1(2H)-yl]methylene}amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: CH₂Cl₂ / 48 h / -10 °C

2.1: lithium bromide; magnesium bromide diethyl etherate / diethyl ether / 1 h / 20 °C

2.2: 1.7 g / CH₂Cl₂; diethyl ether / 5.75 h / -30 °C

3.1: 77 percent / hydrogen / Pd/C / acetonitrile / 2 h / 20 °C / 750.06 Torr

With hydrogen; magnesium bromide ethyl etherate; lithium bromide; palladium on activated charcoal; In diethyl ether; dichloromethane; acetonitrile;
DOI:10.1021/ol051022z