(2R,3R,6S)-1-[(E)-({(1S)-1-[(benzyloxy)methyl]-2-methylpropyl}imino)(phenyl)methyl]-2-methoxy-6-phenylpiperidin-3-ol

Base Information

Chemical Name:(2R,3R,6S)-1-[(E)-({(1S)-1-[(benzyloxy)methyl]-2-methylpropyl}imino)(phenyl)methyl]-2-methoxy-6-phenylpiperidin-3-ol
CAS No.:857899-99-1
Molecular Formula:C₃₁H₃₈N₂O₃
Molecular Weight:486.654
Hs Code.:

Synonyms:(2R,3R,6S)-1-[(E)-({(1S)-1-[(benzyloxy)methyl]-2-methylpropyl}imino)(phenyl)methyl]-2-methoxy-6-phenylpiperidin-3-ol

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Chemical Property of (2R,3R,6S)-1-[(E)-({(1S)-1-[(benzyloxy)methyl]-2-methylpropyl}imino)(phenyl)methyl]-2-methoxy-6-phenylpiperidin-3-ol

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Technology Process of (2R,3R,6S)-1-[(E)-({(1S)-1-[(benzyloxy)methyl]-2-methylpropyl}imino)(phenyl)methyl]-2-methoxy-6-phenylpiperidin-3-ol

There total 5 articles about (2R,3R,6S)-1-[(E)-({(1S)-1-[(benzyloxy)methyl]-2-methylpropyl}imino)(phenyl)methyl]-2-methoxy-6-phenylpiperidin-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 857899-98-0
N-{(1S)-1-[(benzyloxy)methyl]-2-methylpropyl}-N-{(1E)-phenyl[(2S)-2-phenyl-3,4-dihydropyridin-1(2H)-yl]methylene}amine

: 67-56-1
methanol

: 857899-99-1
(2R,3R,6S)-1-[(E)-({(1S)-1-[(benzyloxy)methyl]-2-methylpropyl}imino)(phenyl)methyl]-2-methoxy-6-phenylpiperidin-3-ol

Guidance literature:: With 3,3-dimethyldioxirane; In tetrahydrofuran; acetone; at -78 ℃; for 2h;
DOI:10.1021/ol051022z

Reference yield:

: 857899-97-9
N-{(1S)-1-[(benzyloxy)methyl]-2-methylpropyl}-N-{(1E)-phenyl[(2S)-2-phenylpyridin-1(2H)-yl]methylene}amine

: 857899-99-1
(2R,3R,6S)-1-[(E)-({(1S)-1-[(benzyloxy)methyl]-2-methylpropyl}imino)(phenyl)methyl]-2-methoxy-6-phenylpiperidin-3-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 77 percent / hydrogen / Pd/C / acetonitrile / 2 h / 20 °C / 750.06 Torr

2: 82 percent / dimethyldioxirane / acetone; tetrahydrofuran / 2 h / -78 °C

With hydrogen; 3,3-dimethyldioxirane; palladium on activated charcoal; In tetrahydrofuran; acetone; acetonitrile;
DOI:10.1021/ol051022z

Reference yield:

: Trifluoro-methanesulfonate1-{[(E)-(S)-1-benzyloxymethyl-2-methyl-propylimino]-phenyl-methyl}-pyridinium;

: 857899-99-1
(2R,3R,6S)-1-[(E)-({(1S)-1-[(benzyloxy)methyl]-2-methylpropyl}imino)(phenyl)methyl]-2-methoxy-6-phenylpiperidin-3-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium bromide; magnesium bromide diethyl etherate / diethyl ether / 1 h / 20 °C

1.2: 1.7 g / CH₂Cl₂; diethyl ether / 5.75 h / -30 °C

2.1: 77 percent / hydrogen / Pd/C / acetonitrile / 2 h / 20 °C / 750.06 Torr

3.1: 82 percent / dimethyldioxirane / acetone; tetrahydrofuran / 2 h / -78 °C

With hydrogen; 3,3-dimethyldioxirane; magnesium bromide ethyl etherate; lithium bromide; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; acetone; acetonitrile;
DOI:10.1021/ol051022z