5-(6-{2-[N-(tert-butoxycarbonyl)-N-methylamino]ethoxy}-2,3-difluorobenzyloxy)-2-fluoroaniline

Base Information

Chemical Name:5-(6-{2-[N-(tert-butoxycarbonyl)-N-methylamino]ethoxy}-2,3-difluorobenzyloxy)-2-fluoroaniline
CAS No.:1075700-86-5
Molecular Formula:C₂₁H₂₅F₃N₂O₄
Molecular Weight:426.436
Hs Code.:

Synonyms:5-(6-{2-[N-(tert-butoxycarbonyl)-N-methylamino]ethoxy}-2,3-difluorobenzyloxy)-2-fluoroaniline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-(6-{2-[N-(tert-butoxycarbonyl)-N-methylamino]ethoxy}-2,3-difluorobenzyloxy)-2-fluoroaniline

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Technology Process of 5-(6-{2-[N-(tert-butoxycarbonyl)-N-methylamino]ethoxy}-2,3-difluorobenzyloxy)-2-fluoroaniline

There total 1 articles about 5-(6-{2-[N-(tert-butoxycarbonyl)-N-methylamino]ethoxy}-2,3-difluorobenzyloxy)-2-fluoroaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1075700-85-4
6-(6-{2-[N-(tert-butoxycarbonyl)-N-methylamino]ethoxy}-2,3-difluorobenzyloxy)-3-fluoro-4-nitro-1-bromobenzene

: 1075700-86-5
5-(6-{2-[N-(tert-butoxycarbonyl)-N-methylamino]ethoxy}-2,3-difluorobenzyloxy)-2-fluoroaniline

Guidance literature:: With hydrogen; triethylamine; palladium 10% on activated carbon; In water; ethyl acetate; at 20 ℃;

Reference yield:

: 32315-10-9
bis(trichloromethyl) carbonate

: 1075700-86-5
5-(6-{2-[N-(tert-butoxycarbonyl)-N-methylamino]ethoxy}-2,3-difluorobenzyloxy)-2-fluoroaniline

: 124-41-4
sodium methylate

: 121071-71-4
dimethyl 4-amino-2,3-bismethoxycarbonylthiophene hydrochloride

: 1075701-08-4
3-[5-(6-{2-[N-(tert-butoxycarbonyl)-N-methylamino]-ethoxy}-2,3-difluorobenzyloxy)-2-fluorophenyl]-5-methoxycarbonylthieno[3,4-d]pyrimidine-2,4(1H,3H)-dione

Guidance literature:: bis(trichloromethyl) carbonate; dimethyl 4-amino-2,3-bismethoxycarbonylthiophene hydrochloride; With triethylamine; In ethyl acetate; at 60 ℃; Cooling with ice;

5-(6-{2-[N-(tert-butoxycarbonyl)-N-methylamino]ethoxy}-2,3-difluorobenzyloxy)-2-fluoroaniline; With dmap; In tetrahydrofuran; ethyl acetate; at 60 ℃; for 2h;

sodium methylate; In methanol; at 20 ℃; for 0.5h;