121071-71-4

Usage

Uses

Used in Organic Synthesis:
Dimethyl 4-aminothiophene-2,3-dicarboxylate hydrochloride is used as a synthetic intermediate for the preparation of various organic compounds. Its unique structure and functional groups make it a valuable building block in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Research Laboratories:
Due to its specific applications in scientific areas, Dimethyl 4-aminothiophene-2,3-dicarboxylate hydrochloride is commonly found in research laboratories. It serves as a key component in the development of new synthetic methods and the exploration of novel chemical reactions.
Not commonly found in Consumer Products, Household Goods, or the Natural Environment:
Given its specialized use in scientific research and organic synthesis, Dimethyl 4-aminothiophene-2,3-dicarboxylate hydrochloride is not typically found in consumer products, household goods, or the natural environment. Its presence is mainly limited to controlled laboratory settings where its unique properties can be harnessed for specific applications.

InChI:InChI=1/C8H9NO4S.ClH/c1-12-7(10)5-4(9)3-14-6(5)8(11)13-2;/h3H,9H2,1-2H3;1H

Upstream product

• 38293-63-9 2,3-bismethoxycarbonyl-4-oxotetrahydrothiophene 

Downstream Products

• 1075701-08-4 3-[5-(6-{2-[N-(tert-butoxycarbonyl)-N-methylamino]-ethoxy}-2,3-difluorobenzyloxy)-2-fluorophenyl]-5-methoxycarbonylthieno[3,4-d]pyrimidine-2,4(1H,3H)-dione 
• 1075701-12-0 3-(2-fluoro-5-{2,3-difluoro-6-[2-(oxazolidin-2-one-3-yl)-ethoxy]benzyloxy}phenyl)-5-methoxycarbonylthieno[3,4-d]pyrimidine-2,4(1H,3H)-dione 
• 62947-31-3 dimethyl 4-amino-2,3-bismethoxycarbonylthiophene 

Relevant academic research and scientific papers

A rapid conversion of 3-oxothiolanes into 3-aminothiophenes

3-Oxotetrahydrothiophenes can be rapidly converted into 3-aminothiophenes by refluxing with hydroxylamine hydrochloride in a polar solvent, usually acetonitrile.

The condensed heterocyclic derivative and its intermediate

Provided are an industrially useful method for producing a fused-heterocyclic derivative or salt thereof which is useful as a preventive agent, therapeutic agent, reproductive adjustment agent, contraceptive, ovulation-inducing agent, or sex-hormone-dependent-cancer-post-operation-recurrence preventive agent which target sex-hormone-dependent diseases and the like such as prostate enlargement, uterine myoma, endometriosis, uterine fibroma, precocious puberty, amenorrhea, premenstrual syndrome, dysmenorrhea, polycystic ovary syndrome, lupus erythematosus, hypertrichosis, dwarfism, sleep disorders, acne, baldness, Alzheimer's disease, infertility, irritable bowel syndrome, prostate cancer, uterine cancer, ovarian cancer, breast cancer, and pituitary tumors; and a production intermediate thereof. The present invention makes it possible to produce a compound or salt thereof represented by general formula (A) in high yield and purity by using a compound represented by general formula (D) (R1 and R2 represent identical or different C1-6 alkyl groups, and R3 represents a hydrogen atom, a halogen atom, a C1-6 alkyl group, or a nitro group).

Process for preparing thiophene derivatives

A process for the preparation of 3-aminothiophenes or acid-addition salts thereof, which comprises reacting the corresponding 3-oxotetrahydrothiophenes with an acid-addition salt of hydroxylamine in the presence of a polar inert solvent and in the absence of a base at a temperature in the range of from 0° to 200° C.