methyl 2-(4-(4-(4-(1-methylpiperidine-4-carboxamido)phenyl)butyl)phenyl)acetate

Base Information

Chemical Name:methyl 2-(4-(4-(4-(1-methylpiperidine-4-carboxamido)phenyl)butyl)phenyl)acetate
CAS No.:1579295-42-3
Molecular Formula:C₂₆H₃₄N₂O₃
Molecular Weight:422.568
Hs Code.:

Synonyms:methyl 2-(4-(4-(4-(1-methylpiperidine-4-carboxamido)phenyl)butyl)phenyl)acetate

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Chemical Property of methyl 2-(4-(4-(4-(1-methylpiperidine-4-carboxamido)phenyl)butyl)phenyl)acetate

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Technology Process of methyl 2-(4-(4-(4-(1-methylpiperidine-4-carboxamido)phenyl)butyl)phenyl)acetate

There total 4 articles about methyl 2-(4-(4-(4-(1-methylpiperidine-4-carboxamido)phenyl)butyl)phenyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 1579295-41-2
methyl 2-(4-(4-(4-aminophenyl)butyl)phenyl)acetate

: 71985-80-3,71235-92-2
1-methylpiperidine-4-carboxylic acid hydrochloride

: 1579295-42-3
methyl 2-(4-(4-(4-(1-methylpiperidine-4-carboxamido)phenyl)butyl)phenyl)acetate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 22h;

Reference yield:

: 636-98-6
p-nitrobenzene iodide

: 1579295-42-3
methyl 2-(4-(4-(4-(1-methylpiperidine-4-carboxamido)phenyl)butyl)phenyl)acetate

Guidance literature:: Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide; N-ethyl-N,N-diisopropylamine / 1,2-dimethoxyethane / 2 h / 20 °C

2: palladium 10% on activated carbon; hydrogen / ethyl acetate / 21 h

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 22 h / 20 °C

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; In 1,2-dimethoxyethane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1579295-40-1
methyl 2-(4-(4-(4-nitrophenyl)but-3-ynyl)phenyl)acetate

: 1579295-42-3
methyl 2-(4-(4-(4-(1-methylpiperidine-4-carboxamido)phenyl)butyl)phenyl)acetate

Guidance literature:: Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 21 h

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 22 h / 20 °C

With palladium 10% on activated carbon; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In ethyl acetate; N,N-dimethyl-formamide;