N-(4-(4-(4-(2-(hydroxyamino)-2-oxoethyl)phenyl)butyl)phenyl)-1-methylpiperidine-4-carboxamide

Base Information

Chemical Name:N-(4-(4-(4-(2-(hydroxyamino)-2-oxoethyl)phenyl)butyl)phenyl)-1-methylpiperidine-4-carboxamide
CAS No.:1579294-59-9
Molecular Formula:C₂₅H₃₃N₃O₃
Molecular Weight:423.555
Hs Code.:

Synonyms:N-(4-(4-(4-(2-(hydroxyamino)-2-oxoethyl)phenyl)butyl)phenyl)-1-methylpiperidine-4-carboxamide

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Chemical Property of N-(4-(4-(4-(2-(hydroxyamino)-2-oxoethyl)phenyl)butyl)phenyl)-1-methylpiperidine-4-carboxamide

Chemical Property:

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Technology Process of N-(4-(4-(4-(2-(hydroxyamino)-2-oxoethyl)phenyl)butyl)phenyl)-1-methylpiperidine-4-carboxamide

There total 5 articles about N-(4-(4-(4-(2-(hydroxyamino)-2-oxoethyl)phenyl)butyl)phenyl)-1-methylpiperidine-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 14.0%

: 1579295-42-3
methyl 2-(4-(4-(4-(1-methylpiperidine-4-carboxamido)phenyl)butyl)phenyl)acetate

: 1579294-59-9
N-(4-(4-(4-(2-(hydroxyamino)-2-oxoethyl)phenyl)butyl)phenyl)-1-methylpiperidine-4-carboxamide

Guidance literature:: With hydroxylamine; sodium methylate; In methanol; water; at 0 - 20 ℃; for 2h;

Reference yield:

: 636-98-6
p-nitrobenzene iodide

: 1579294-59-9
N-(4-(4-(4-(2-(hydroxyamino)-2-oxoethyl)phenyl)butyl)phenyl)-1-methylpiperidine-4-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide; N-ethyl-N,N-diisopropylamine / 1,2-dimethoxyethane / 2 h / 20 °C

2: palladium 10% on activated carbon; hydrogen / ethyl acetate / 21 h

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 22 h / 20 °C

4: sodium methylate; hydroxylamine / methanol; water / 2 h / 0 - 20 °C

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; hydroxylamine; sodium methylate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; In methanol; 1,2-dimethoxyethane; water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1579295-40-1
methyl 2-(4-(4-(4-nitrophenyl)but-3-ynyl)phenyl)acetate

: 1579294-59-9
N-(4-(4-(4-(2-(hydroxyamino)-2-oxoethyl)phenyl)butyl)phenyl)-1-methylpiperidine-4-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 21 h

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 22 h / 20 °C

3: sodium methylate; hydroxylamine / methanol; water / 2 h / 0 - 20 °C

With palladium 10% on activated carbon; hydrogen; hydroxylamine; sodium methylate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In methanol; water; ethyl acetate; N,N-dimethyl-formamide;