tert-butyl 6-((4-(2-(2-methoxy-2-oxoethyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-3,4-dihydroisoquinoline-2(1H)-carboxylate

Base Information

Chemical Name:tert-butyl 6-((4-(2-(2-methoxy-2-oxoethyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-3,4-dihydroisoquinoline-2(1H)-carboxylate
CAS No.:1393901-39-7
Molecular Formula:C₃₀H₃₃F₃N₄O₄
Molecular Weight:570.612
Hs Code.:

Synonyms:tert-butyl 6-((4-(2-(2-methoxy-2-oxoethyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-3,4-dihydroisoquinoline-2(1H)-carboxylate

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Chemical Property of tert-butyl 6-((4-(2-(2-methoxy-2-oxoethyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-3,4-dihydroisoquinoline-2(1H)-carboxylate

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Technology Process of tert-butyl 6-((4-(2-(2-methoxy-2-oxoethyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-3,4-dihydroisoquinoline-2(1H)-carboxylate

There total 11 articles about tert-butyl 6-((4-(2-(2-methoxy-2-oxoethyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-3,4-dihydroisoquinoline-2(1H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 164148-92-9
tert-butyl 6-amino-3,4-dihydroisoquinoline-2(1H)-carboxylate

: 1393653-49-0
methyl 2-(2-(2-(2-(methylsulfonyl)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetate

: 1393901-39-7
tert-butyl 6-((4-(2-(2-methoxy-2-oxoethyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-3,4-dihydroisoquinoline-2(1H)-carboxylate

Guidance literature:: tert-butyl 6-amino-3,4-dihydroisoquinoline-2(1H)-carboxylate; methyl 2-(2-(2-(2-(methylsulfonyl)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetate; With trifluoroacetic acid; In 2,2,2-trifluoroethanol; at 20 - 100 ℃; for 0.366667h; Sonication; Microwave irradiation;

With di-tert-butyl dicarbonate; In dichloromethane; for 18h;

Reference yield: 54.0%

: 164148-92-9
tert-butyl 6-amino-3,4-dihydroisoquinoline-2(1H)-carboxylate

: 24424-99-5
di-tert-butyl dicarbonate

: 1393653-49-0
methyl 2-(2-(2-(2-(methylsulfonyl)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetate

: 1393901-39-7
tert-butyl 6-((4-(2-(2-methoxy-2-oxoethyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-3,4-dihydroisoquinoline-2(1H)-carboxylate

Guidance literature:: tert-butyl 6-amino-3,4-dihydroisoquinoline-2(1H)-carboxylate; methyl 2-(2-(2-(2-(methylsulfonyl)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetate; With trifluoroacetic acid; In 2,2,2-trifluoroethanol; at 100 ℃; for 0.333333h; microwave irradiation;

di-tert-butyl dicarbonate; In dichloromethane; for 18h;

Reference yield:

: 66370-75-0
methyl (2-iodophenyl)acetate

: 1393901-39-7
tert-butyl 6-((4-(2-(2-methoxy-2-oxoethyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-3,4-dihydroisoquinoline-2(1H)-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

2.1: tetrabutyl ammonium fluoride / dichloromethane; tetrahydrofuran / 1 h / 0 - 20 °C

3.1: triethylamine / triphenylphosphine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / dichloromethane / 0.17 h / 100 °C / Inert atmosphere; microwave irradiation

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C

5.1: hydrogen / palladium 10% on activated carbon / N,N-dimethyl-formamide / 16 h / 20 °C

6.1: trifluoroacetic acid / 2,2,2-trifluoroethanol / 0.33 h / 100 °C / microwave irradiation

6.2: 18 h

With tetrabutyl ammonium fluoride; hydrogen; triethylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; palladium 10% on activated carbon; triphenylphosphine; In tetrahydrofuran; dichloromethane; 2,2,2-trifluoroethanol; N,N-dimethyl-formamide;