N-{4-[2-tert-Butyl-4-(6-methyl-2-oxo-1,2-dihydro-pyridin-3-yl)-quinazolin-7-yl]-phenyl}-methanesulfonamide

Base Information

Chemical Name:N-{4-[2-tert-Butyl-4-(6-methyl-2-oxo-1,2-dihydro-pyridin-3-yl)-quinazolin-7-yl]-phenyl}-methanesulfonamide
CAS No.:1354455-79-0
Molecular Formula:C₂₅H₂₆N₄O₃S
Molecular Weight:462.572
Hs Code.:

Synonyms:N-{4-[2-tert-Butyl-4-(6-methyl-2-oxo-1,2-dihydro-pyridin-3-yl)-quinazolin-7-yl]-phenyl}-methanesulfonamide

Suppliers and Price of N-{4-[2-tert-Butyl-4-(6-methyl-2-oxo-1,2-dihydro-pyridin-3-yl)-quinazolin-7-yl]-phenyl}-methanesulfonamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-{4-[2-tert-Butyl-4-(6-methyl-2-oxo-1,2-dihydro-pyridin-3-yl)-quinazolin-7-yl]-phenyl}-methanesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-{4-[2-tert-Butyl-4-(6-methyl-2-oxo-1,2-dihydro-pyridin-3-yl)-quinazolin-7-yl]-phenyl}-methanesulfonamide

There total 7 articles about N-{4-[2-tert-Butyl-4-(6-methyl-2-oxo-1,2-dihydro-pyridin-3-yl)-quinazolin-7-yl]-phenyl}-methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1354455-89-2
C₂₆H₂₈N₄O₃S

: 1354455-79-0
N-{4-[2-tert-Butyl-4-(6-methyl-2-oxo-1,2-dihydro-pyridin-3-yl)-quinazolin-7-yl]-phenyl}-methanesulfonamide

Guidance literature:: C₂₆H₂₈N₄O₃S; With hydrogen bromide; acetic acid; In water; at 60 ℃; for 3h; Sealed tube;

With sodium hydrogencarbonate; In water; ethyl acetate;

Reference yield:

: 3282-30-2
pivaloyl chloride

: 1354455-79-0
N-{4-[2-tert-Butyl-4-(6-methyl-2-oxo-1,2-dihydro-pyridin-3-yl)-quinazolin-7-yl]-phenyl}-methanesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / dichloromethane / 0 °C / Inert atmosphere

1.2: 0 - 20 °C

2.1: sodium hydroxide / ethanol; water / 1.5 h / Inert atmosphere; Reflux

3.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; methanol / 115 °C / Inert atmosphere; Microwave irradiation; Sealed tube

4.1: N,N-diethylaniline; trichlorophosphate / benzene / 6 h / Reflux

5.1: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 1 h / Inert atmosphere; Sealed tube; Heating

6.1: hydrogen bromide; acetic acid / water / 3 h / 60 °C / Sealed tube

With hydrogen bromide; sodium carbonate; caesium carbonate; acetic acid; triethylamine; N,N-diethylaniline; sodium hydroxide; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; methanol; ethanol; dichloromethane; water; toluene; benzene; 3.1: Suzuki Coupling / 5.1: Suzuki Coupling;

Reference yield:

: 1354455-87-0
C₁₉H₂₁N₃O₃S

: 1354455-79-0
N-{4-[2-tert-Butyl-4-(6-methyl-2-oxo-1,2-dihydro-pyridin-3-yl)-quinazolin-7-yl]-phenyl}-methanesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: N,N-diethylaniline; trichlorophosphate / benzene / 6 h / Reflux

2: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 1 h / Inert atmosphere; Sealed tube; Heating

3: hydrogen bromide; acetic acid / water / 3 h / 60 °C / Sealed tube

With hydrogen bromide; caesium carbonate; acetic acid; N,N-diethylaniline; trichlorophosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; water; benzene; 2: Suzuki Coupling;