7-Methyl 8-(phenylmethyl) 1,4-dioxa-8-azaspiro[4.5]decane-7,8-dicarboxylate

Base Information

Chemical Name:7-Methyl 8-(phenylmethyl) 1,4-dioxa-8-azaspiro[4.5]decane-7,8-dicarboxylate
CAS No.:125104-21-4
Molecular Formula:C₁₇H₂₁NO₆
Molecular Weight:335.357
Hs Code.:
DSSTox Substance ID:DTXSID001143566

Synonyms:7-Methyl 8-(phenylmethyl) 1,4-dioxa-8-azaspiro[4.5]decane-7,8-dicarboxylate;SCHEMBL9734819;JRZCHVMZHVLDPT-UHFFFAOYSA-N;DTXSID001143566;125104-21-4

Suppliers and Price of 7-Methyl 8-(phenylmethyl) 1,4-dioxa-8-azaspiro[4.5]decane-7,8-dicarboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 7-Methyl 8-(phenylmethyl) 1,4-dioxa-8-azaspiro[4.5]decane-7,8-dicarboxylate

Chemical Property:

XLogP3:1.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:5
Exact Mass:335.13688739
Heavy Atom Count:24
Complexity:456

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC(=O)C1CC2(CCN1C(=O)OCC3=CC=CC=C3)OCCO2

Technology Process of 7-Methyl 8-(phenylmethyl) 1,4-dioxa-8-azaspiro[4.5]decane-7,8-dicarboxylate

There total 3 articles about 7-Methyl 8-(phenylmethyl) 1,4-dioxa-8-azaspiro[4.5]decane-7,8-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 125104-19-0
(±)-methyl 1-benzyloxycarbonyl-4-oxopiperidine-2-carboxylate

: 107-21-1
ethylene glycol

: 125104-21-4
7-methyl 8-(phenylmethyl) 1,4-dioxa-8-azaspiro<4.5>decane-7,8-dicarboxylate

Guidance literature:: With 4 A molecular sieve; toluene-4-sulfonic acid; In benzene; for 4h; Heating;
DOI:10.1021/jm00081a009

Reference yield:

: 104-15-4
toluene-4-sulfonic acid

: 107-21-1
ethylene glycol

: 125104-21-4
7-methyl 8-(phenylmethyl) 1,4-dioxa-8-azaspiro<4.5>decane-7,8-dicarboxylate

Guidance literature:: silica gel; In benzene;

Reference yield:

: 125104-17-8
2-Methyl 1-(phenylmethyl) 3,4-dihydro-4-oxo-1,2(2H)-pyridinedicarboxylate

: 125104-21-4
7-methyl 8-(phenylmethyl) 1,4-dioxa-8-azaspiro<4.5>decane-7,8-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) Me₂PhSiH, (Ph₃P)3RhCl, 2.) 40percent aq. HF / 1.) 50 deg C, 3 h, 2.) acetonitrile, RT, 18 h

2: 99 percent / PTSA, 4 Angstroem molecular sieves / benzene / 4 h / Heating

With Wilkinson's catalyst; 4 A molecular sieve; Dimethylphenylsilane; hydrogen fluoride; toluene-4-sulfonic acid; In benzene;
DOI:10.1021/jm00081a009