6-Methyl-2-thioxo-1,2-dihydro-pyridine-3-carboxylic acid (2,6-dichloro-phenyl)-amide

Base Information

• Chemical Name: 6-Methyl-2-thioxo-1,2-dihydro-pyridine-3-carboxylic acid (2,6-dichloro-phenyl)-amide
• CAS No.: 102818-05-3
• Molecular Formula: C₁₃H₁₀Cl₂N₂OS
• Molecular Weight: 313.207

Synonyms:6-Methyl-2-thioxo-1,2-dihydro-pyridine-3-carboxylic acid (2,6-dichloro-phenyl)-amide

Chemical Property of 6-Methyl-2-thioxo-1,2-dihydro-pyridine-3-carboxylic acid (2,6-dichloro-phenyl)-amide

Chemical Property:

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Technology Process of 6-Methyl-2-thioxo-1,2-dihydro-pyridine-3-carboxylic acid (2,6-dichloro-phenyl)-amide

There total 2 articles about 6-Methyl-2-thioxo-1,2-dihydro-pyridine-3-carboxylic acid (2,6-dichloro-phenyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

4-methoxy-3-buten-2-one (4652-27-1) + N-(2,6-dichlorophenyl)-2-thiocarbamoylacetamide (102834-67-3) → 6-Methyl-2-thioxo-1,2-dihydro-pyridine-3-carboxylic acid (2,6-dichloro-phenyl)-amide (102818-05-3)

Guidance literature:

With piperdinium acetate; In ethanol; for 10h; Heating;

DOI:10.1055/s-1985-31365

Reference yield:

2-Cyano-N-(2,6-dichloro-phenyl)-acetamide (64204-39-3) → 6-Methyl-2-thioxo-1,2-dihydro-pyridine-3-carboxylic acid (2,6-dichloro-phenyl)-amide (102818-05-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / H₂S, (C₂H₅)3N / pyridine

2: 37 percent / piperidine acetate / ethanol / 10 h / Heating

With hydrogen sulfide; piperdinium acetate; triethylamine; In pyridine; ethanol;

DOI:10.1055/s-1985-31365

Reference yield: 71.0%

6-Methyl-2-thioxo-1,2-dihydro-pyridine-3-carboxylic acid (2,6-dichloro-phenyl)-amide (102818-05-3) → 2-(2,6-Dichloro-phenyl)-6-methyl-isothiazolo[5,4-b]pyridin-3-one (102818-16-6)

Guidance literature:

With sodium hydroxide; iodine; In ethanol; for 0.0833333h; Ambient temperature;

DOI:10.1055/s-1985-31365

upstream raw materials:

4-methoxy-3-buten-2-one

N-(2,6-dichlorophenyl)-2-thiocarbamoylacetamide

2-Cyano-N-(2,6-dichloro-phenyl)-acetamide

Downstream raw materials:

2-(2,6-Dichloro-phenyl)-6-methyl-isothiazolo[5,4-b]pyridin-3-one

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