4652-27-1

Basic information

• Product Name: 4-METHOXY-3-BUTEN-2-ONE
• Synonyms: 4-METHOXY-3-BUTEN-2-ONE;TRANS-1-METHOXY-1-BUTEN-3-ONE;TRANS-4-METHOXY-3-BUTEN-2-ONE;4-methoxybut-3-en-2-one;4-Methoxy-3-buten-2-one, tech., 90%;4-Methoxy-3-buten-2-one, 90%,tech;1-Methoxy-1-buten-3-one;2-Methoxyvinyl methyl ketone
• CAS NO: 4652-27-1
• Molecular Formula: C₅H₈O₂
• Molecular Weight: 100.12
• EINECS: 257-364-0
• Mol File: 4652-27-1.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 200 °C(lit.)
• Flash Point: 146 °F
• Appearance: Clear yellow/Liquid
• Density: 0.982 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.332mmHg at 25°C
• Refractive Index: n20/D 1.468(lit.)
• Storage Temp.: 2-8°C
• Solubility: Miscible with tetrahydrofuran, ether, acetonitrile and benzene.
• BRN: 1741053
• CAS DataBase Reference: 4-METHOXY-3-BUTEN-2-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-METHOXY-3-BUTEN-2-ONE(4652-27-1)
• EPA Substance Registry System: 4-METHOXY-3-BUTEN-2-ONE(4652-27-1)

Safety Data

• Safety Statements: 23-24/25
• WGK Germany: 3
• F: 10-21
• Hazardous Substances Data: 4652-27-1(Hazardous Substances Data)

Usage

Chemical Properties

clear yellow liquid

Uses

4-Methoxy-3-buten-2-one is an important precursor for the synthesis of 1-methoxy-3-trimethylsilyloxy-1,3-butadiene and the Danishefsky diene and its equivalent. It is widely used as a reactant in the synthesis of hydroisoquinoline derivatives. It is employed as an intermediate for the synthesis of manzamine.

InChI:InChI=1/C5H8O2/c1-5(6)3-4-7-2/h3-4H,1-2H3/b4-3-

Upstream product

• 5436-21-5 acetylacetaldehyde dimethyl acetal 
• 2798-73-4 1-methoxy-buten-3-yne 
• 67-56-1 methanol 
• 999-69-9 4-methoxycarbonyloxy-but-3-en-2-one 
• 67-64-1 acetone 
• 77-78-1 dimethyl sulfate 
• 109-94-4 formic acid ethyl ester 
• 34713-70-7 2-Phenylpropanal 
• 59414-23-2 1-methoxy-3-<(trimethylsilyl)oxy>01,3-butadiene 
• 41125-09-1 3-oxo-butyraldehyde; sodium enolate 
• 593-60-2 Vinyl bromide 
• 2798-73-4 (Z)-1-methoxybut-1-en-3-yne 
• 54125-02-9 danishefsky's diene 
• 434-45-7 2,2,2-Trifluoroacetophenone 

Downstream Products

• 6051-55-4 (3E)-4-morpholinyl-3-buten-2-one 
• 108-52-1 4-Methyl-pyrimidin-2-ylamin 
• 14042-04-7 acetoacetaldehyde bis-(4-nitro-phenylhydrazone) 
• 67560-24-1 4c-(5-phenyl-[1,2,4]oxadiazol-3-ylamino)-but-3-en-2-one 
• 4376-23-2 (E)-hex-3-en-2-one 
• 5622-24-2 N-<3-Oxo-buten-(1)-yl>-isatinsaeure 
• 5622-21-9 1-<4-Hydroxy-anilino>-buten-(1)-on-(3) 
• 5622-31-1 1-<2-Carboxy-phenylamino>-buten-(1)-on-(3) 
• 5622-20-8 1-(4-Hydroxy-3-carboxy-phenylamino)-buten-⁽¹⁾-on-⁽³⁾ 
• 5622-30-0 1-<4-Nitro-phenylamino>-buten-(1)-on-(3) 
• 55370-62-2 1-(5-benzoyl-isoxazol-3-yl)-ethanone 
• 55370-63-3 C,C',C''-(4,5-dihydro-isoxazole-3,4r,5t-triyl)-C,C',C''-triphenyl-tris-methanone 
• 18992-67-1 1,2-dimethyl-9H-carbazole 
• 59414-23-2 1-methoxy-3-<(trimethylsilyl)oxy>01,3-butadiene 

Relevant articles and documents

High Pressure Reaction of 1-Methoxy-3-trialkylsiloxybuta-1,3-diene with Aldehydes. Cycloaddition or Silicon Migration Reaction

The high pressure reaction of Danishefsky's diene with aromatic aldehydes produces the cycloadduct, while with an aliphatic aldehyde such as 2-phenylpropionaldehyde the intermolecular silicon migration from oxygen to oxygen takes place.

Identification and synthesis of elymniafuran, a new monoterpene from the butterfly elymnias thryallis

The main constituent of the scent gland secretion of the tropical butterfly Elymnias thryallis (Lepidoptera: Satyridae) could be identified as (S)-2-methyl-1-(4-methyl-2-furyl)-3-buten-2-ol (elymniafuran, 3). It is accompanied by small amounts of (E)- and (Z)-4-methyl-(2-methyl-1,3-butadienyl)-furan (4) as well as the spiro acetal 3,9-dimethyl-1,6-dioxaspiro[4.5]dec-3-ene (10). The structural assignment of these new natural products as well as the synthesis and enantiomeric separation by chiral gas chromatography are described. VCH Verlagsgesellschaft mbH, 1996.

Chlorination of α,β-Unsaturated Ketones and Esters in the Presence of Acid Scavengers

The chlorination of a series of α,β-unsaturated ketones and esters by Cl2 in CH3OH, with and without acid scavengers such as N-chlorosuccinimide (NCS), pyridine and 2,6-lutidine, is described.Methyl vinyl ketone and cyclohex-2-enone have also been chlorinated in ethanol.Mixtures of Markovnikov(M) and anti-Markovnikov(AM) methoxy chlorides and dichlorides are formed in most cases; phenyl vinyl ketone gives no M products in the absence of pyridine, M methoxy chloride is not formed with (E)-4-chlorobut-3-en-2-one under any conditions, pyridine has no effect on the product ratios and methyl 3-chlorobut-2-enoate forms only dichloride.Chlorination of the ketones in the presence of the pyridines results in a significant increase in the M regioisomer (except for methyl isopropenyl ketone and the ketones mentioned), giving M : AM ratios which are similar to the corresponding esters.Ratios for the esters are not affected significantly by pyridine.We ascribe the effect of the pyridine bases to the elimination of acid and the acid-catalysed mechanism, permitting the chlorination to occur via a carbon-carbon ?-bond (chloronium ion) mechanism.The rate of chlorination of methyl vinyl ketone is retarded by pyridine but is still considerably faster than methyl acrylate.NCS, in contrast to N-bromosuccinimide (NBS) reported previously, has no effect on the M : AM ratio.The chlorination of methyl vinyl ketone with NCS and HCl gives markedly different results from Cl2.