methyl 2-O-benzoyl-4-O-benzyl-3-O-chloroacetyl-6-O-(t-butyldiphenylsilyl)-1-thio-β-D-glucopyranoside

Base Information

Chemical Name:methyl 2-O-benzoyl-4-O-benzyl-3-O-chloroacetyl-6-O-(t-butyldiphenylsilyl)-1-thio-β-D-glucopyranoside
CAS No.:476313-23-2
Molecular Formula:C₃₉H₄₃ClO₇SSi
Molecular Weight:719.371
Hs Code.:

Synonyms:methyl 2-O-benzoyl-4-O-benzyl-3-O-chloroacetyl-6-O-(t-butyldiphenylsilyl)-1-thio-β-D-glucopyranoside

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Chemical Property of methyl 2-O-benzoyl-4-O-benzyl-3-O-chloroacetyl-6-O-(t-butyldiphenylsilyl)-1-thio-β-D-glucopyranoside

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Technology Process of methyl 2-O-benzoyl-4-O-benzyl-3-O-chloroacetyl-6-O-(t-butyldiphenylsilyl)-1-thio-β-D-glucopyranoside

There total 7 articles about methyl 2-O-benzoyl-4-O-benzyl-3-O-chloroacetyl-6-O-(t-butyldiphenylsilyl)-1-thio-β-D-glucopyranoside which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 541-88-8
Chloroacetic anhydride

: 476313-34-5
methyl 2-O-benzoyl-4-O-benzyl-6-O-(t-butyldiphenylsilyl)-1-thio-β-D-glucopyranoside

: 476313-23-2
methyl 2-O-benzoyl-4-O-benzyl-3-O-chloroacetyl-6-O-(t-butyldiphenylsilyl)-1-thio-β-D-glucopyranoside

Guidance literature:: With pyridine; In dichloromethane; at 0 ℃;
DOI:10.1021/ja020781z

Reference yield:

: 98-88-4
benzoyl chloride

: 476313-23-2
methyl 2-O-benzoyl-4-O-benzyl-3-O-chloroacetyl-6-O-(t-butyldiphenylsilyl)-1-thio-β-D-glucopyranoside

Guidance literature:: Multi-step reaction with 4 steps

1: 75 percent / DMAP; pyridine / 80 °C

2: BH₃*NMe₃; AlCl₃; MS 4A / CH₂Cl₂; diethyl ether / 4 h / 0 °C

3: 13.85 g / Et₃N; DMAP / CH₂Cl₂ / 20 °C

4: 92 percent / pyridine / CH₂Cl₂ / 0 °C

With pyridine; dmap; aluminium trichloride; trimethylamine-borane; triethylamine; In diethyl ether; dichloromethane;
DOI:10.1021/ja020781z

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 476313-23-2
methyl 2-O-benzoyl-4-O-benzyl-3-O-chloroacetyl-6-O-(t-butyldiphenylsilyl)-1-thio-β-D-glucopyranoside

Guidance literature:: Multi-step reaction with 2 steps

1: 13.85 g / Et₃N; DMAP / CH₂Cl₂ / 20 °C

2: 92 percent / pyridine / CH₂Cl₂ / 0 °C

With pyridine; dmap; triethylamine; In dichloromethane;
DOI:10.1021/ja020781z