N-(4-t-butylphenyl)-4-(pyridin-4-ylmethylamino)-1H-indole-3-carboxamide

Base Information

Chemical Name:N-(4-t-butylphenyl)-4-(pyridin-4-ylmethylamino)-1H-indole-3-carboxamide
CAS No.:1149359-55-6
Molecular Formula:C₂₅H₂₆N₄O
Molecular Weight:398.508
Hs Code.:

Synonyms:N-(4-t-butylphenyl)-4-(pyridin-4-ylmethylamino)-1H-indole-3-carboxamide

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Chemical Property of N-(4-t-butylphenyl)-4-(pyridin-4-ylmethylamino)-1H-indole-3-carboxamide

Chemical Property:

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Technology Process of N-(4-t-butylphenyl)-4-(pyridin-4-ylmethylamino)-1H-indole-3-carboxamide

There total 5 articles about N-(4-t-butylphenyl)-4-(pyridin-4-ylmethylamino)-1H-indole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1149360-31-5
C₁₆H₁₅N₃O₂

: 769-92-6
4-tert-Butylaniline

: 1149359-55-6
N-(4-t-butylphenyl)-4-(pyridin-4-ylmethylamino)-1H-indole-3-carboxamide

Guidance literature:: With trimethylaluminum; In hexane; toluene; for 1h; Inert atmosphere; Reflux;
DOI:10.1016/j.bmcl.2011.01.063

Reference yield:

: 1149360-30-4
methyl 4-amino-1H-indole-3-carboxylate

: 1149359-55-6
N-(4-t-butylphenyl)-4-(pyridin-4-ylmethylamino)-1H-indole-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid / methanol / 1 h / 20 °C

2: sodium cyanoborohydride / methanol / 1 h / 20 °C

3: trimethylaluminum / hexane; toluene / 1 h / Inert atmosphere; Reflux

With trimethylaluminum; sodium cyanoborohydride; acetic acid; In methanol; hexane; toluene;
DOI:10.1016/j.bmcl.2011.01.063

Reference yield:

: 942-24-5
3-methoxycarbonylindole

: 1149359-55-6
N-(4-t-butylphenyl)-4-(pyridin-4-ylmethylamino)-1H-indole-3-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: nitric acid; acetic acid / 50 - 85 °C

2: palladium 10% on activated carbon; hydrogen / methanol / 4 h / 20 °C

3: acetic acid / methanol / 1 h / 20 °C

4: sodium cyanoborohydride / methanol / 1 h / 20 °C

5: trimethylaluminum / hexane; toluene / 1 h / Inert atmosphere; Reflux

With palladium 10% on activated carbon; hydrogen; trimethylaluminum; nitric acid; sodium cyanoborohydride; acetic acid; In methanol; hexane; toluene;
DOI:10.1016/j.bmcl.2011.01.063