{1-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-carbamic acid 2-(4-nitro-phenyl)-ethyl ester

Base Information

Chemical Name:{1-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-carbamic acid 2-(4-nitro-phenyl)-ethyl ester
CAS No.:109205-75-6
Molecular Formula:C₄₅H₅₂N₄O₁₀Si
Molecular Weight:837.014
Hs Code.:

{1-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-carbamic acid 2-(4-nitro-phenyl)-ethyl ester

Synonyms:{1-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-carbamic acid 2-(4-nitro-phenyl)-ethyl ester

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Chemical Property of {1-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-carbamic acid 2-(4-nitro-phenyl)-ethyl ester

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Technology Process of {1-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-carbamic acid 2-(4-nitro-phenyl)-ethyl ester

There total 3 articles about {1-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-carbamic acid 2-(4-nitro-phenyl)-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 109205-71-2
2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-N⁴-{[2-(4-nitrophenyl)ethoxy]carbonyl}cytidine

: 109205-75-6
{1-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-carbamic acid 2-(4-nitro-phenyl)-ethyl ester

Guidance literature:: With 1H-imidazole; In pyridine; for 18h; Ambient temperature;
DOI:10.1002/hlca.19980810106

Reference yield:

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 109205-75-6
{1-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-carbamic acid 2-(4-nitro-phenyl)-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / Et₃N, 4-(dimethylamino)pyridine / pyridine / 5 h / Ambient temperature

2: 98 percent / 1H-imidazole / pyridine / 18 h / Ambient temperature

With 1H-imidazole; dmap; triethylamine; In pyridine;
DOI:10.1002/hlca.19980810106

Reference yield:

: 88091-67-2
2'-deoxy-N⁴-{[2-(4-nitrophenyl)ethoxy]carbonyl}cytidine

: 109205-75-6
{1-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-carbamic acid 2-(4-nitro-phenyl)-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / Et₃N, 4-(dimethylamino)pyridine / pyridine / 5 h / Ambient temperature

2: 98 percent / 1H-imidazole / pyridine / 18 h / Ambient temperature

With 1H-imidazole; dmap; triethylamine; In pyridine;
DOI:10.1002/hlca.19980810106