4-Amino-1-[(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-1H-pyrimidin-2-one

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Chemical Name:4-Amino-1-[(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-1H-pyrimidin-2-one
CAS No.:102434-70-8
Molecular Formula:C₃₆H₄₅N₃O₆Si
Molecular Weight:643.855
Hs Code.:

Synonyms:4-Amino-1-[(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-1H-pyrimidin-2-one

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Chemical Property of 4-Amino-1-[(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-1H-pyrimidin-2-one

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Technology Process of 4-Amino-1-[(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-1H-pyrimidin-2-one

There total 5 articles about 4-Amino-1-[(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-1H-pyrimidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 109205-75-6
{1-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-carbamic acid 2-(4-nitro-phenyl)-ethyl ester

: 102434-70-8
4-Amino-1-[(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-1H-pyrimidin-2-one

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In pyridine; for 18h;
DOI:10.1002/hlca.19980810106

Reference yield:

: 76512-82-8
5'-O-(4,4'-dimethoxytrityl)deoxycytidine

: 18162-48-6
tert-butyldimethylsilyl chloride

: 102434-70-8
4-Amino-1-[(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-1H-pyrimidin-2-one

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 20h;

Reference yield:

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 102434-70-8
4-Amino-1-[(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-1H-pyrimidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: 86 percent / Et₃N, 4-(dimethylamino)pyridine / pyridine / 5 h / Ambient temperature

2: 98 percent / 1H-imidazole / pyridine / 18 h / Ambient temperature

3: 97 percent / DBU / pyridine / 18 h

With 1H-imidazole; dmap; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In pyridine;
DOI:10.1002/hlca.19980810106