Methyl 2,5-bis(2,2,2-trifluoroethoxy)benzoate

Base Information

• Chemical Name: Methyl 2,5-bis(2,2,2-trifluoroethoxy)benzoate
• CAS No.: 175204-89-4
• Molecular Formula: C9H7F3O4
• Molecular Weight: 236.147
• Mol file: 175204-89-4.mol

Synonyms:METHYL 2,5-DI(TRIFLUOROETHOXY)BENZOATE;METHYL 2,5-BIS(2,2,2-TRIFLUOROETHOXY)BENZOATE;METHYL 2,5-BIS(TRIFLUOROETHOXY)BENZOATE;METHYL 2,5-DI(2,2,2-TRIFLUOROETHOXY)BENZOATE;Methyl2,5-Bis(2,2,2-trifluoroethoxy)Benzoate95+%;Methyl 2,5-bis(trifluorothoxy)benzoate

Chemical Property of Methyl 2,5-bis(2,2,2-trifluoroethoxy)benzoate

Chemical Property:

• Melting Point: 40 °C
• PSA: 44.76000
• LogP: 3.35540

Purity/Quality:

99% ^*data from raw suppliers

Methyl2-hydroxy-5-(trifluoromethoxy)benzoate 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 2,5-bis(2,2,2-trifluoroethoxy)benzoate

There total 2 articles about Methyl 2,5-bis(2,2,2-trifluoroethoxy)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methanol (67-56-1) + TFMSA (129644-57-1) → methyl 2-hydroxy-5-(trifluoromethoxy)benzoate (175204-89-4)

Guidance literature:

With sulfuric acid; at 120 ℃; for 1h; Microwave irradiation;

Reference yield:

TFMSA (129644-57-1) + diazomethyl-trimethyl-silane (18107-18-1) → methyl 2-hydroxy-5-(trifluoromethoxy)benzoate (175204-89-4)

Guidance literature:

In methanol; dichloromethane; at 0 - 25 ℃; for 3h;

Reference yield: 100.0%

methyl 2-hydroxy-5-(trifluoromethoxy)benzoate (175204-89-4) → methyl 2-hydroxy-3-nitro-5-(trifluoromethoxy)benzoate (935534-17-1)

Guidance literature:

With sulfuric acid; nitric acid; In dichloromethane; at 0 ℃;

DOI:10.1021/acs.jmedchem.9b01411

upstream raw materials:

methanol

TFMSA

diazomethyl-trimethyl-silane

Downstream raw materials:

methyl 5-(trifluoromethoxy)-2-{[(trifluoromethyl)sulfonyl]oxy}benzoate

methyl 2-hydroxy-3-nitro-5-(trifluoromethoxy)benzoate

methyl 3-amino-2-hydroxy-5-(trifluoromethoxy)benzoate