(-)-2-(trimethylsilyl)ethyl (2S)-3,3-difluoro-2-{[(1R)-1-phenyl-2-methoxyethyl]amino}-2-(2-phenylallyl)-5-hexenoate

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Chemical Name:(-)-2-(trimethylsilyl)ethyl (2S)-3,3-difluoro-2-{[(1R)-1-phenyl-2-methoxyethyl]amino}-2-(2-phenylallyl)-5-hexenoate
CAS No.:911395-46-5
Molecular Formula:C₂₉H₃₉F₂NO₃Si
Molecular Weight:515.716
Hs Code.:

Synonyms:(-)-2-(trimethylsilyl)ethyl (2S)-3,3-difluoro-2-{[(1R)-1-phenyl-2-methoxyethyl]amino}-2-(2-phenylallyl)-5-hexenoate

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Chemical Property of (-)-2-(trimethylsilyl)ethyl (2S)-3,3-difluoro-2-{[(1R)-1-phenyl-2-methoxyethyl]amino}-2-(2-phenylallyl)-5-hexenoate

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Technology Process of (-)-2-(trimethylsilyl)ethyl (2S)-3,3-difluoro-2-{[(1R)-1-phenyl-2-methoxyethyl]amino}-2-(2-phenylallyl)-5-hexenoate

There total 6 articles about (-)-2-(trimethylsilyl)ethyl (2S)-3,3-difluoro-2-{[(1R)-1-phenyl-2-methoxyethyl]amino}-2-(2-phenylallyl)-5-hexenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: (-)-2-(trimethylsilyl)ethyl 3,3-difluoro-2-{[(1R)-1-phenyl-2-methoxyethyl]imino}-5-hexenoate

: 3360-54-1
3-bromo-2-phenylprop-1-ene

: 911395-46-5
(-)-2-(trimethylsilyl)ethyl (2S)-3,3-difluoro-2-{[(1R)-1-phenyl-2-methoxyethyl]amino}-2-(2-phenylallyl)-5-hexenoate

Guidance literature:: With ammonium chloride; In tetrahydrofuran; at 20 ℃; for 1h;
DOI:10.1021/ol061733c

Reference yield: 50.0%

: 911395-34-1
C₂₀H₂₉F₂NO₃Si

: 3360-54-1
3-bromo-2-phenylprop-1-ene

: 911395-46-5
(-)-2-(trimethylsilyl)ethyl (2S)-3,3-difluoro-2-{[(1R)-1-phenyl-2-methoxyethyl]amino}-2-(2-phenylallyl)-5-hexenoate

Guidance literature:: With ammonium chloride; zinc; In tetrahydrofuran; water; at 20 ℃; optical yield given as %de; diastereoselective reaction;
DOI:10.1002/chem.200702009

Reference yield:

: (-)-N-[(1R)-2-methoxy-1-phenylethyl]-1-chloro-2,2-difluoro-4-pentenimidoyl chloride

: 911395-46-5
(-)-2-(trimethylsilyl)ethyl (2S)-3,3-difluoro-2-{[(1R)-1-phenyl-2-methoxyethyl]amino}-2-(2-phenylallyl)-5-hexenoate

Guidance literature:: Multi-step reaction with 3 steps

1: NaI / acetone / 20 °C

2: 51 percent / K₂CO₃; Pd₂(dba)3*CHCl₃ / toluene; dimethylformamide / 20 °C / 760 Torr

3: 50 percent / aq. NH₄Cl / tetrahydrofuran / 1 h / 20 °C

With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; potassium carbonate; ammonium chloride; sodium iodide; In tetrahydrofuran; N,N-dimethyl-formamide; acetone; toluene;
DOI:10.1021/ol061733c