(R)-5-((3-(methoxymethoxy)hexyl)sulfonyl)-1-phenyl-1H-tetrazole

Base Information

• Chemical Name: (R)-5-((3-(methoxymethoxy)hexyl)sulfonyl)-1-phenyl-1H-tetrazole
• CAS No.: 782498-27-5
• Molecular Formula: C₁₅H₂₂N₄O₄S
• Molecular Weight: 354.43
• Mol file: 782498-27-5.mol

Synonyms:(R)-5-((3-(methoxymethoxy)hexyl)sulfonyl)-1-phenyl-1H-tetrazole

Chemical Property of (R)-5-((3-(methoxymethoxy)hexyl)sulfonyl)-1-phenyl-1H-tetrazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-5-((3-(methoxymethoxy)hexyl)sulfonyl)-1-phenyl-1H-tetrazole

There total 7 articles about (R)-5-((3-(methoxymethoxy)hexyl)sulfonyl)-1-phenyl-1H-tetrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

(R)-5-((3-(methoxymethoxy)hexyl)thio)-1-phenyl-1H-tetrazole (782498-34-4) → (R)-5-((3-(methoxymethoxy)hexyl)sulfonyl)-1-phenyl-1H-tetrazole (782498-27-5)

Guidance literature:

With ammonium molybdate tetrahydrate; dihydrogen peroxide; In ethanol; at 0 - 20 ℃; for 8h;

DOI:10.1039/c4ob00965g

Reference yield:

(2R,3R)-2,3-epoxy-1-hexanol (92418-71-8) → (R)-5-((3-(methoxymethoxy)hexyl)sulfonyl)-1-phenyl-1H-tetrazole (782498-27-5)

Guidance literature:

Multi-step reaction with 6 steps

1: Red-Al

2: ethyldiisopropylamine

3: ethyldiisopropylamine

4: TBAF

5: DEAD; n-Bu₃P

6: 85 percent / mCPBA; NaHCO₃

With tributylphosphine; tetrabutyl ammonium fluoride; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; sodium bis(2-methoxyethoxy)aluminium dihydride; diethylazodicarboxylate; 5: Mitsunobu reaction;

DOI:10.1021/jo061070c

Reference yield:

(R)-3-(methoxymethoxy)hexan-1-ol → (R)-5-((3-(methoxymethoxy)hexyl)sulfonyl)-1-phenyl-1H-tetrazole (782498-27-5)

Guidance literature:

Multi-step reaction with 2 steps

1: DEAD; n-Bu₃P

2: 85 percent / mCPBA; NaHCO₃

With tributylphosphine; sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; diethylazodicarboxylate; 1: Mitsunobu reaction;

DOI:10.1021/jo061070c

upstream raw materials:

(R)-5-((3-(methoxymethoxy)hexyl)thio)-1-phenyl-1H-tetrazole

tert-butyl-(3-methoxymethoxy-hexyloxy)-diphenyl-silane

(2R,3R)-2,3-epoxy-1-hexanol

(R)-(-)-hexane-1,3-diol

Downstream raw materials:

(R)-E-1,2,3-trimethoxy-5-(4-(methoxymethoxy)hept-1-en-1-yl)benzene

(S)-E-1-(3,4,5-trimethoxyphenyl)hept-1-en-4-yl-4-nitrobenzoate

(S)-E-1-(3,4,5-trimethoxyphenyl)hept-1-en-4-ol

(2R,3R,5R)-5-propyl-2-(3,4,5-trimethoxyphenyl)tetrahydrofuran-3-ol