2-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}-5-({[2-oxo-1-(2-pyridinylmethyl)-1,2-dihydro-4-pyrimidinyl]oxy}methyl)benzonitrile

Base Information

Chemical Name:2-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}-5-({[2-oxo-1-(2-pyridinylmethyl)-1,2-dihydro-4-pyrimidinyl]oxy}methyl)benzonitrile
CAS No.:1381791-20-3
Molecular Formula:C₂₅H₁₆ClF₃N₄O₃
Molecular Weight:512.875
Hs Code.:

Synonyms:2-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}-5-({[2-oxo-1-(2-pyridinylmethyl)-1,2-dihydro-4-pyrimidinyl]oxy}methyl)benzonitrile

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Chemical Property of 2-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}-5-({[2-oxo-1-(2-pyridinylmethyl)-1,2-dihydro-4-pyrimidinyl]oxy}methyl)benzonitrile

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Technology Process of 2-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}-5-({[2-oxo-1-(2-pyridinylmethyl)-1,2-dihydro-4-pyrimidinyl]oxy}methyl)benzonitrile

There total 6 articles about 2-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}-5-({[2-oxo-1-(2-pyridinylmethyl)-1,2-dihydro-4-pyrimidinyl]oxy}methyl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1381791-23-6
2-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}-5-{[(2-oxo-2,3-dihydro-4-pyrimidinyl)oxy]methyl}benzonitrile

: 6959-47-3
2-chloromethylpyridine hydrochloride

: 1381791-20-3
2-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}-5-({[2-oxo-1-(2-pyridinylmethyl)-1,2-dihydro-4-pyrimidinyl]oxy}methyl)benzonitrile

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 110 ℃; for 2h; Irradiation;

Reference yield:

: 1354962-25-6
2-(4-chloro-3-(trifluoromethyl)phenoxy)-5-formylbenzonitrile

: 1381791-20-3
2-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}-5-({[2-oxo-1-(2-pyridinylmethyl)-1,2-dihydro-4-pyrimidinyl]oxy}methyl)benzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: sodium tetrahydroborate; methanol / 0.5 h / 0 - 20 °C

2: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.67 h / 0 °C

3: potassium carbonate; 1,4-diaza-bicyclo[2.2.2]octane; water / 1,4-dioxane / 3 h / 70 °C

4: caesium carbonate / N,N-dimethyl-formamide / 2 h / 110 °C / Irradiation

With 1,4-diaza-bicyclo[2.2.2]octane; methanol; sodium tetrahydroborate; water; sodium hydride; potassium carbonate; caesium carbonate; In 1,4-dioxane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1369255-73-1
2-(4-chloro-3-(trifluoromethyl)phenoxy)-5-(hydroxymethyl)benzylnitrile

: 1381791-20-3
2-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}-5-({[2-oxo-1-(2-pyridinylmethyl)-1,2-dihydro-4-pyrimidinyl]oxy}methyl)benzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.67 h / 0 °C

2: potassium carbonate; 1,4-diaza-bicyclo[2.2.2]octane; water / 1,4-dioxane / 3 h / 70 °C

3: caesium carbonate / N,N-dimethyl-formamide / 2 h / 110 °C / Irradiation

With 1,4-diaza-bicyclo[2.2.2]octane; water; sodium hydride; potassium carbonate; caesium carbonate; In 1,4-dioxane; N,N-dimethyl-formamide; mineral oil;