4-(4-fluorophenyl)-6-(hydroxymethyl)-2-(oxan-2-yl)-2,3-dihydropyridazin-3-one

Base Information

Chemical Name:4-(4-fluorophenyl)-6-(hydroxymethyl)-2-(oxan-2-yl)-2,3-dihydropyridazin-3-one
CAS No.:1591827-47-2
Molecular Formula:C₁₆H₁₇FN₂O₃
Molecular Weight:304.321
Hs Code.:

Synonyms:4-(4-fluorophenyl)-6-(hydroxymethyl)-2-(oxan-2-yl)-2,3-dihydropyridazin-3-one

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Chemical Property of 4-(4-fluorophenyl)-6-(hydroxymethyl)-2-(oxan-2-yl)-2,3-dihydropyridazin-3-one

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Technology Process of 4-(4-fluorophenyl)-6-(hydroxymethyl)-2-(oxan-2-yl)-2,3-dihydropyridazin-3-one

There total 5 articles about 4-(4-fluorophenyl)-6-(hydroxymethyl)-2-(oxan-2-yl)-2,3-dihydropyridazin-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1591827-46-1
6-[[(tert-butyldiphenylsilyl)oxy]methyl]-4-(4-fluorophenyl)-2-(oxan-2-yl)-2,3-dihydropyridazin-3-one

: 1591827-47-2
4-(4-fluorophenyl)-6-(hydroxymethyl)-2-(oxan-2-yl)-2,3-dihydropyridazin-3-one

Guidance literature:: With sodium hydrogencarbonate; In tetrahydrofuran; Petroleum ether;

Reference yield:

: 1591827-44-9
ethyl 5-((tert-butyldiphenylsilyl)oxy)-2-(4-fluorophenyl)-2-hydroxy-4-oxopentanoate

: 1591827-47-2
4-(4-fluorophenyl)-6-(hydroxymethyl)-2-(oxan-2-yl)-2,3-dihydropyridazin-3-one

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid; hydrazine hydrate / 5.5 h / 20 - 80 °C / Inert atmosphere

2: toluene-4-sulfonic acid / toluene / 90 °C / Inert atmosphere

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.58 h / 20 °C / Inert atmosphere

With tetrabutyl ammonium fluoride; toluene-4-sulfonic acid; hydrazine hydrate; acetic acid; In tetrahydrofuran; toluene;

Reference yield:

: 352-13-6
4-flourophenylmagnesium bromide

: 1591827-47-2
4-(4-fluorophenyl)-6-(hydroxymethyl)-2-(oxan-2-yl)-2,3-dihydropyridazin-3-one

Guidance literature:: Multi-step reaction with 5 steps

1: tetrahydrofuran / -78 - -20 °C / Inert atmosphere

2: acetic acid; pyrrolidine / 85 °C / Sealed tube; Inert atmosphere

3: acetic acid; hydrazine hydrate / 5.5 h / 20 - 80 °C / Inert atmosphere

4: toluene-4-sulfonic acid / toluene / 90 °C / Inert atmosphere

5: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.58 h / 20 °C / Inert atmosphere

With pyrrolidine; tetrabutyl ammonium fluoride; toluene-4-sulfonic acid; hydrazine hydrate; acetic acid; In tetrahydrofuran; toluene;