6-[[(tert-butyldiphenylsilyl)oxy]methyl]-4-(4-fluorophenyl)-2-(oxan-2-yl)-2,3-dihydropyridazin-3-one

Base Information

Chemical Name:6-[[(tert-butyldiphenylsilyl)oxy]methyl]-4-(4-fluorophenyl)-2-(oxan-2-yl)-2,3-dihydropyridazin-3-one
CAS No.:1591827-46-1
Molecular Formula:C₃₂H₃₅FN₂O₃Si
Molecular Weight:542.725
Hs Code.:

Synonyms:6-[[(tert-butyldiphenylsilyl)oxy]methyl]-4-(4-fluorophenyl)-2-(oxan-2-yl)-2,3-dihydropyridazin-3-one

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Chemical Property of 6-[[(tert-butyldiphenylsilyl)oxy]methyl]-4-(4-fluorophenyl)-2-(oxan-2-yl)-2,3-dihydropyridazin-3-one

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Technology Process of 6-[[(tert-butyldiphenylsilyl)oxy]methyl]-4-(4-fluorophenyl)-2-(oxan-2-yl)-2,3-dihydropyridazin-3-one

There total 4 articles about 6-[[(tert-butyldiphenylsilyl)oxy]methyl]-4-(4-fluorophenyl)-2-(oxan-2-yl)-2,3-dihydropyridazin-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 110-87-2
3,4-dihydro-2H-pyran

: 1591827-45-0
6-[[(tert-butyldiphenylsilyl)oxy]methyl]-4-(4-fluorophenyl)-2,3-dihydropyridazin-3-one

: 1591827-46-1
6-[[(tert-butyldiphenylsilyl)oxy]methyl]-4-(4-fluorophenyl)-2-(oxan-2-yl)-2,3-dihydropyridazin-3-one

Guidance literature:: With toluene-4-sulfonic acid; In toluene; at 90 ℃; Inert atmosphere;

Reference yield:

: 1591827-44-9
ethyl 5-((tert-butyldiphenylsilyl)oxy)-2-(4-fluorophenyl)-2-hydroxy-4-oxopentanoate

: 1591827-46-1
6-[[(tert-butyldiphenylsilyl)oxy]methyl]-4-(4-fluorophenyl)-2-(oxan-2-yl)-2,3-dihydropyridazin-3-one

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid; hydrazine hydrate / 5.5 h / 20 - 80 °C / Inert atmosphere

2: toluene-4-sulfonic acid / toluene / 90 °C / Inert atmosphere

With toluene-4-sulfonic acid; hydrazine hydrate; acetic acid; In toluene;

Reference yield:

: 352-13-6
4-flourophenylmagnesium bromide

: 1591827-46-1
6-[[(tert-butyldiphenylsilyl)oxy]methyl]-4-(4-fluorophenyl)-2-(oxan-2-yl)-2,3-dihydropyridazin-3-one

Guidance literature:: Multi-step reaction with 4 steps

1: tetrahydrofuran / -78 - -20 °C / Inert atmosphere

2: acetic acid; pyrrolidine / 85 °C / Sealed tube; Inert atmosphere

3: acetic acid; hydrazine hydrate / 5.5 h / 20 - 80 °C / Inert atmosphere

4: toluene-4-sulfonic acid / toluene / 90 °C / Inert atmosphere

With pyrrolidine; toluene-4-sulfonic acid; hydrazine hydrate; acetic acid; In tetrahydrofuran; toluene;