ethyl 3-[1-(2-chloro-4-fluorophenyl)-2-(4-methoxyphenyl)-4-oxo-5-piperidin-1-yl-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-3-yl]acrylate

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Chemical Name:ethyl 3-[1-(2-chloro-4-fluorophenyl)-2-(4-methoxyphenyl)-4-oxo-5-piperidin-1-yl-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-3-yl]acrylate
CAS No.:1069136-88-4
Molecular Formula:C₃₀H₃₁ClFN₃O₄
Molecular Weight:552.045
Hs Code.:

Synonyms:ethyl 3-[1-(2-chloro-4-fluorophenyl)-2-(4-methoxyphenyl)-4-oxo-5-piperidin-1-yl-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-3-yl]acrylate

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Chemical Property of ethyl 3-[1-(2-chloro-4-fluorophenyl)-2-(4-methoxyphenyl)-4-oxo-5-piperidin-1-yl-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-3-yl]acrylate

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Technology Process of ethyl 3-[1-(2-chloro-4-fluorophenyl)-2-(4-methoxyphenyl)-4-oxo-5-piperidin-1-yl-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-3-yl]acrylate

There total 5 articles about ethyl 3-[1-(2-chloro-4-fluorophenyl)-2-(4-methoxyphenyl)-4-oxo-5-piperidin-1-yl-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-3-yl]acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1069136-87-3
1-(2-chloro-4-fluorophenyl)-3-iodo-2-(4-methoxyphenyl)-5-piperidin-1-yl-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one

: 140-88-5,9003-32-1
ethyl acrylate

: 1069136-88-4
ethyl 3-[1-(2-chloro-4-fluorophenyl)-2-(4-methoxyphenyl)-4-oxo-5-piperidin-1-yl-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-3-yl]acrylate

Guidance literature:: With tetrabutyl-ammonium chloride; sodium carbonate; palladium diacetate; In N,N-dimethyl-formamide; at 80 ℃; for 4.41667h;

Reference yield:

: 2632-13-5
2-Bromo-4'-methoxyacetophenone

: 1069136-88-4
ethyl 3-[1-(2-chloro-4-fluorophenyl)-2-(4-methoxyphenyl)-4-oxo-5-piperidin-1-yl-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-3-yl]acrylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran / 0.25 h / 0 °C

1.2: 1.75 h / 0 °C

2.1: N-iodo-succinimide / N,N-dimethyl-formamide / 20 °C

3.1: tetrabutyl-ammonium chloride; sodium carbonate / palladium diacetate / N,N-dimethyl-formamide / 4.42 h / 80 °C

With N-iodo-succinimide; tetrabutyl-ammonium chloride; sodium hydride; sodium carbonate; palladium diacetate; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 932739-14-5
4-(2-chloro-4-fluorophenylamino)-5,6,3',4',5',6'-hexahydro-2'H-[1,1']bipyridinyl-2-one

: 1069136-88-4
ethyl 3-[1-(2-chloro-4-fluorophenyl)-2-(4-methoxyphenyl)-4-oxo-5-piperidin-1-yl-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-3-yl]acrylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran / 0.25 h / 0 °C

1.2: 1.75 h / 0 °C

2.1: N-iodo-succinimide / N,N-dimethyl-formamide / 20 °C

3.1: tetrabutyl-ammonium chloride; sodium carbonate / palladium diacetate / N,N-dimethyl-formamide / 4.42 h / 80 °C

With N-iodo-succinimide; tetrabutyl-ammonium chloride; sodium hydride; sodium carbonate; palladium diacetate; In tetrahydrofuran; N,N-dimethyl-formamide;