(3aS,3bR,9bR,10R,11S,11aS)-2,2-dimethyl-4-(4-methylphenylsulfonyl)-10-phenylcarbonyloxy-11-(tert-butyldimethylsilyloxy)-7,8-di(trimethylsilyl)-3a,3b,4,5,9b,10,11,11a-octahydro[1,3]dioxolo[4,5-c]phenanthridine

Base Information

• Chemical Name: (3aS,3bR,9bR,10R,11S,11aS)-2,2-dimethyl-4-(4-methylphenylsulfonyl)-10-phenylcarbonyloxy-11-(tert-butyldimethylsilyloxy)-7,8-di(trimethylsilyl)-3a,3b,4,5,9b,10,11,11a-octahydro[1,3]dioxolo[4,5-c]phenanthridine
• CAS No.: 872221-80-2
• Molecular Formula: C₄₂H₆₁NO₇SSi₃
• Molecular Weight: 808.271
• Mol file: 872221-80-2.mol

Synonyms:(3aS,3bR,9bR,10R,11S,11aS)-2,2-dimethyl-4-(4-methylphenylsulfonyl)-10-phenylcarbonyloxy-11-(tert-butyldimethylsilyloxy)-7,8-di(trimethylsilyl)-3a,3b,4,5,9b,10,11,11a-octahydro[1,3]dioxolo[4,5-c]phenanthridine

Chemical Property of (3aS,3bR,9bR,10R,11S,11aS)-2,2-dimethyl-4-(4-methylphenylsulfonyl)-10-phenylcarbonyloxy-11-(tert-butyldimethylsilyloxy)-7,8-di(trimethylsilyl)-3a,3b,4,5,9b,10,11,11a-octahydro[1,3]dioxolo[4,5-c]phenanthridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3aS,3bR,9bR,10R,11S,11aS)-2,2-dimethyl-4-(4-methylphenylsulfonyl)-10-phenylcarbonyloxy-11-(tert-butyldimethylsilyloxy)-7,8-di(trimethylsilyl)-3a,3b,4,5,9b,10,11,11a-octahydro[1,3]dioxolo[4,5-c]phenanthridine

There total 1 articles about (3aS,3bR,9bR,10R,11S,11aS)-2,2-dimethyl-4-(4-methylphenylsulfonyl)-10-phenylcarbonyloxy-11-(tert-butyldimethylsilyloxy)-7,8-di(trimethylsilyl)-3a,3b,4,5,9b,10,11,11a-octahydro[1,3]dioxolo[4,5-c]phenanthridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

(3aS,4S,5R,6R,7R,7aS)-2,2-dimethyl-7-(4-methylphenyl(2-propynyl)sulfonamido)-4-(tert-butyldimethylsilyloxy)-5-phenylcarbonyloxy-6-(1-ethynyl)perhydro-1,3-benzodioxole (872221-77-7) + Bis(trimethylsilyl)ethyne (14630-40-1) → (3aS,3bR,9bR,10R,11S,11aS)-2,2-dimethyl-4-(4-methylphenylsulfonyl)-10-phenylcarbonyloxy-11-(tert-butyldimethylsilyloxy)-7,8-di(trimethylsilyl)-3a,3b,4,5,9b,10,11,11a-octahydro[1,3]dioxolo[4,5-c]phenanthridine (872221-80-2)

Guidance literature:

dicarbonylcyclopentadienylcobalt; In xylene; at 140 ℃;

DOI:10.1021/ol052372o

Reference yield: 99.0%

(3aS,3bR,9bR,10R,11S,11aS)-2,2-dimethyl-4-(4-methylphenylsulfonyl)-10-phenylcarbonyloxy-11-(tert-butyldimethylsilyloxy)-7,8-di(trimethylsilyl)-3a,3b,4,5,9b,10,11,11a-octahydro[1,3]dioxolo[4,5-c]phenanthridine (872221-80-2) → (3aS,3bR,9bR,10R,11S,11aS)-2,2-dimethyl-4-(4-methylphenylsulfonyl)-11-(tert-butyldimethylsilyloxy)-7,8-di(trimethylsilyl)-3a,3b,4,5,9b,10,11,11a-octahydro[1,3]dioxolo[4,5-c]phenanthridin-10-ol (872221-81-3)

Guidance literature:

With sodium methylate; In tetrahydrofuran; methanol; at 20 ℃; for 0.166667h;

DOI:10.1021/ol052372o

Reference yield: 85.0%

(3aS,3bR,9bR,10R,11S,11aS)-2,2-dimethyl-4-(4-methylphenylsulfonyl)-10-phenylcarbonyloxy-11-(tert-butyldimethylsilyloxy)-7,8-di(trimethylsilyl)-3a,3b,4,5,9b,10,11,11a-octahydro[1,3]dioxolo[4,5-c]phenanthridine (872221-80-2) → (3aS,3bR,9bR,10R,11S,11aR)-11-hydroxy-2,2-dimethyl-4-(4-methylphenylsulfonyl)-10-phenylcarbonyloxy-7,8-di(trimethylsilyl)-3a,3b,4,5,9b,10,11,11a-octahydro[1,3]dioxolo[4,5-c]phenanthridine (872221-85-7)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃;

DOI:10.1139/V06-078

upstream raw materials:

(3aS,4S,5R,6R,7R,7aS)-2,2-dimethyl-7-(4-methylphenyl(2-propynyl)sulfonamido)-4-(tert-butyldimethylsilyloxy)-5-phenylcarbonyloxy-6-(1-ethynyl)perhydro-1,3-benzodioxole

Bis(trimethylsilyl)ethyne

Downstream raw materials:

(3aS,3bR,9bR,10R,11S,11aR)-11-hydroxy-2,2-dimethyl-4-(4-methylphenylsulfonyl)-10-phenylcarbonyloxy-7,8-di(trimethylsilyl)-3a,3b,4,5,9b,10,11,11a-octahydro[1,3]dioxolo[4,5-c]phenanthridine

(3aS,3bR,9bR,10R,11S,11aS)-2,2-dimethyl-4-(4-methylphenylsulfonyl)-11-(tert-butyldimethylsilyloxy)-7,8-di(trimethylsilyl)-3a,3b,4,5,9b,10,11,11a-octahydro[1,3]dioxolo[4,5-c]phenanthridin-10-ol

(3aS,3bR,9bR,10R,11S,11aR)-2,2-dimethyl-4-(4-methylphenylsulfonyl)-7,8-di(trimethylsilyl)-3a,3b,4,5,9b,10,11,11a-octahydro[1,3]dioxolo[4,5-c]phenanthridine-10,11-diol

(3aS,3bR,9bR,10R,11S,11aS)-2,2-dimethyl-4-(4-methylphenylsulfonyl)-10,11-di(phenylcarbonyloxy)-7,8-di(trimethylsilyl)-3a,3b,4,5,9b,10,11,11a-octahydro[1,3]dioxolo[4,5-c]phenanthridine