N-(benzyloxycarbonyl)leucine amide of (2S,3R,4S)-2-amino-1-cyclohexyl-3,4-dihydroxy-6-methylheptane

Base Information

Chemical Name:N-(benzyloxycarbonyl)leucine amide of (2S,3R,4S)-2-amino-1-cyclohexyl-3,4-dihydroxy-6-methylheptane
CAS No.:146879-05-2
Molecular Formula:C₂₈H₄₆N₂O₅
Molecular Weight:490.684
Hs Code.:

Synonyms:N-(benzyloxycarbonyl)leucine amide of (2S,3R,4S)-2-amino-1-cyclohexyl-3,4-dihydroxy-6-methylheptane

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Chemical Property of N-(benzyloxycarbonyl)leucine amide of (2S,3R,4S)-2-amino-1-cyclohexyl-3,4-dihydroxy-6-methylheptane

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Technology Process of N-(benzyloxycarbonyl)leucine amide of (2S,3R,4S)-2-amino-1-cyclohexyl-3,4-dihydroxy-6-methylheptane

There total 2 articles about N-(benzyloxycarbonyl)leucine amide of (2S,3R,4S)-2-amino-1-cyclohexyl-3,4-dihydroxy-6-methylheptane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2018-66-8
Z-Leu-OH

: 146879-05-2
N-(benzyloxycarbonyl)leucine amide of (2S,3R,4S)-2-amino-1-cyclohexyl-3,4-dihydroxy-6-methylheptane

Guidance literature:: Multi-step reaction with 2 steps

1: N-methylmorpholine / CH₂Cl₂ / 0.05 h / -10 °C

2: CH₂Cl₂ / 1.) -10 deg C, 10 min, 2.) RT, 2 h

With 4-methyl-morpholine; In dichloromethane;
DOI:10.1021/jm00056a005

Reference yield:

: 104882-10-2
(2S,3R,4S)-2-[(tert-butyloxycarbonyl)amino]-1-cyclohexyl-3,4-dihydroxy-6-methylheptane

: 146879-05-2
N-(benzyloxycarbonyl)leucine amide of (2S,3R,4S)-2-amino-1-cyclohexyl-3,4-dihydroxy-6-methylheptane

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / 4 M HCl / dioxane / 1 h / Ambient temperature

2: CH₂Cl₂ / 1.) -10 deg C, 10 min, 2.) RT, 2 h

With hydrogenchloride; In 1,4-dioxane; dichloromethane;
DOI:10.1021/jm00056a005