104882-10-2

Basic information

• Product Name: (2S,3R,4S)-2-[(tert-butyloxycarbonyl)amino]-1-cyclohexyl-3,4-dihydroxy-6-methylheptane
• Synonyms: (2S,3R,4S)-2-[(tert-butyloxycarbonyl)amino]-1-cyclohexyl-3,4-dihydroxy-6-methylheptane
• CAS NO: 104882-10-2
• Molecular Weight: 343.507
• Mol File: 104882-10-2.mol
• Article Data: 24

Chemical Properties

• CAS DataBase Reference: (2S,3R,4S)-2-[(tert-butyloxycarbonyl)amino]-1-cyclohexyl-3,4-dihydroxy-6-methylheptane(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,3R,4S)-2-[(tert-butyloxycarbonyl)amino]-1-cyclohexyl-3,4-dihydroxy-6-methylheptane(104882-10-2)
• EPA Substance Registry System: (2S,3R,4S)-2-[(tert-butyloxycarbonyl)amino]-1-cyclohexyl-3,4-dihydroxy-6-methylheptane(104882-10-2)

Safety Data

• Hazardous Substances Data: 104882-10-2(Hazardous Substances Data)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 104882-45-3 (S)-2-amino-1-cyclohexyl-(R)-3,(S)-4-dihydroxy-6-methylheptane hydrochloride 
• 122621-77-6 (2S,3R,4S)-2-amino-1-cyclohexyl-3,4-dihydroxy-6-methylheptane 
• 131550-34-0 (S)-2-Cyclohexyl-1-((4R,5S)-5-isobutyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-ethylamine 
• 5674-02-2 2-methylpropylmagnesium chloride 
• 117499-02-2 ((S)-2-Cyano-1-cyclohexylmethyl-2-trimethylsilanyloxy-ethyl)-carbamic acid tert-butyl ester 
• 114457-87-3 (2S,3R)-2-<(tert-butyloxycarbonyl)amino>-1-cyclohexyl-3-hydroxy-6-methylheptan-4-one 
• 119618-56-3 2(S)-t-Butyloxycarbonylamino-1-cyclohexyl-6-methylhept-3-ene 
• 104882-08-8 cis-(2S)-2<(tert-butyloxycarbonyl)amino>-1-cyclohexyl-6-methylhept-3-ene 
• 63-91-2 L-phenylalanine 
• 27527-05-5 L-cyclohexylalanine 
• 126773-90-8 2(S)-(N,N-dibenzylamino)-3-cyclohexylpropionic acid 
• 176715-45-0 (S)-3-Cyclohexyl-2-dibenzylamino-propionaldehyde 
• 176715-44-9 (2S)-3-cyclohexyl-2-(dibenzylamino)propan-1-ol 

Downstream Products

• 122621-77-6 (2S,3R,4S)-2-amino-1-cyclohexyl-3,4-dihydroxy-6-methylheptane 
• 117161-13-4 (4S,5R)-4-cyclohexylmethyl-5-<(1'S)-1'-hydroxy-3-methylbutyl>oxazolidin-2-one 

Relevant articles and documents

A diastereoselective synthesis of (2S, 3R, 4S)-2-amino-1-cyclohexyl-6-methylheptane-3,4-diol, the Abbott aminodiol

An efficient asymmetric synthesis of the Abbott aminodiol, 1, is described beginning with the readily-available starting material, L-phenylalanine.

Enantioselective synthesis of the (syn,anti)-1-amino-2,3-diol subunit of renin inhibition by reaction of β-lactams with a Grignard reagent

A new approach to the BOC-protected amino diol 1a via the opening of 3,4-cis-disubstituted β-lactam 3 with isobutylmagnesium chloride is described. Nonracemic β-lactam 3 could be obtained by enzymatic resolution of the 3-acetoxy-β-lactam 4 or from a chira

3-AZABICYCLO[3.2.1]-NONANYL-TERMINATED NON-PIPTIDYL ALPHA-SUCCINAMIDOACYL AMINODIOLS AS ANTI-HYPERTENSIVE AGENTS

Non-peptidyl compounds characterized generally as α-succinamidoacyl aminodiols having a 3-azabicyclo[3.2.2]-nonanyl-type group at the N-terminus are useful as renin inhibitors for the treatment of hypertension.