(+/-)-2-(4-isopropyl-1,4-dimethyl-5-oxo-4,5-dihydro-1H-imidazol-2-yl)benzoic acid

Base Information

Chemical Name:(+/-)-2-(4-isopropyl-1,4-dimethyl-5-oxo-4,5-dihydro-1H-imidazol-2-yl)benzoic acid
CAS No.:1276021-19-2
Molecular Formula:C₁₅H₁₈N₂O₃
Molecular Weight:274.32
Hs Code.:

Synonyms:(+/-)-2-(4-isopropyl-1,4-dimethyl-5-oxo-4,5-dihydro-1H-imidazol-2-yl)benzoic acid

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Chemical Property of (+/-)-2-(4-isopropyl-1,4-dimethyl-5-oxo-4,5-dihydro-1H-imidazol-2-yl)benzoic acid

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Technology Process of (+/-)-2-(4-isopropyl-1,4-dimethyl-5-oxo-4,5-dihydro-1H-imidazol-2-yl)benzoic acid

There total 4 articles about (+/-)-2-(4-isopropyl-1,4-dimethyl-5-oxo-4,5-dihydro-1H-imidazol-2-yl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 124-38-9,18923-20-1
carbon dioxide

: 1276021-18-1
(+/-)-2-(2-bromophenyl)-4-isopropyl-1,4-dimethyl-4,5-dihydro-1H-imidazol-5-one

: 1276021-19-2
(+/-)-2-(4-isopropyl-1,4-dimethyl-5-oxo-4,5-dihydro-1H-imidazol-2-yl)benzoic acid

Guidance literature:: (+/-)-2-(2-bromophenyl)-4-isopropyl-1,4-dimethyl-4,5-dihydro-1H-imidazol-5-one; With isopropylmagnesium chloride; In tetrahydrofuran; diethyl ether; at 0 ℃; for 0.5h; Inert atmosphere;

carbon dioxide; In tetrahydrofuran; diethyl ether; Inert atmosphere; Cooling;

With hydrogenchloride; water; pH=3;
DOI:10.1016/j.jorganchem.2010.10.031

Reference yield:

: 125768-22-1
(+/-)-2-(2-bromophenyl)-4-isopropyl-4-methyl-4,5-dihydro-1H-imidazol-5-one

: 1276021-19-2
(+/-)-2-(4-isopropyl-1,4-dimethyl-5-oxo-4,5-dihydro-1H-imidazol-2-yl)benzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium tert-butylate / N,N-dimethyl-formamide / 24 h / 0 - 20 °C / Inert atmosphere

2.1: isopropylmagnesium chloride / tetrahydrofuran; diethyl ether / 0.5 h / 0 °C / Inert atmosphere

2.2: Inert atmosphere; Cooling

2.3: pH 3

With potassium tert-butylate; isopropylmagnesium chloride; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide;
DOI:10.1016/j.jorganchem.2010.10.031

Reference yield:

: 40963-14-2
2-amino-2,3-dimethylbutyramide

: 1276021-19-2
(+/-)-2-(4-isopropyl-1,4-dimethyl-5-oxo-4,5-dihydro-1H-imidazol-2-yl)benzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / dichloromethane / 5 h / 0 - 20 °C

2.1: potassium hydroxide / methanol / 240 h / 20 °C

2.2: pH 6

3.1: potassium tert-butylate / N,N-dimethyl-formamide / 24 h / 0 - 20 °C / Inert atmosphere

4.1: isopropylmagnesium chloride / tetrahydrofuran; diethyl ether / 0.5 h / 0 °C / Inert atmosphere

4.2: Inert atmosphere; Cooling

4.3: pH 3

With potassium tert-butylate; isopropylmagnesium chloride; triethylamine; potassium hydroxide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.jorganchem.2010.10.031