α,α-bis(4-fluorophenyl)-1-[(4-methylphenyl)sulfonyl]-3-piperidinepropanenitrile

Base Information

Chemical Name:α,α-bis(4-fluorophenyl)-1-[(4-methylphenyl)sulfonyl]-3-piperidinepropanenitrile
CAS No.:131912-10-2
Molecular Formula:C₂₇H₂₆F₂N₂O₂S
Molecular Weight:480.578
Hs Code.:

Synonyms:α,α-bis(4-fluorophenyl)-1-[(4-methylphenyl)sulfonyl]-3-piperidinepropanenitrile

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of α,α-bis(4-fluorophenyl)-1-[(4-methylphenyl)sulfonyl]-3-piperidinepropanenitrile

Chemical Property:

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Technology Process of α,α-bis(4-fluorophenyl)-1-[(4-methylphenyl)sulfonyl]-3-piperidinepropanenitrile

There total 4 articles about α,α-bis(4-fluorophenyl)-1-[(4-methylphenyl)sulfonyl]-3-piperidinepropanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4606-65-9
3-(hydroxymethy)piperidine

: 131912-10-2
α,α-bis(4-fluorophenyl)-1-[(4-methylphenyl)sulfonyl]-3-piperidinepropanenitrile

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / 17.5 h / Ambient temperature

2: 1.) NaH / 1.) DMSO, RT, 1 h, 2.) DMSO, 60 deg C, 15 h

With pyridine; sodium hydride;
DOI:10.1021/jm00114a009

Reference yield:

: 98-59-9
p-toluenesulfonyl chloride

: 131912-10-2
α,α-bis(4-fluorophenyl)-1-[(4-methylphenyl)sulfonyl]-3-piperidinepropanenitrile

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / 17.5 h / Ambient temperature

2: 1.) NaH / 1.) DMSO, RT, 1 h, 2.) DMSO, 60 deg C, 15 h

With pyridine; sodium hydride;
DOI:10.1021/jm00114a009