2-(3-aminomethyl-4-methoxy-phenyl)-5-methyl-2H-pyrazole-3-carboxylic acid (2'-tert-butylsulfamoyl-biphenyl-4-yl)-amide

Base Information

Chemical Name:2-(3-aminomethyl-4-methoxy-phenyl)-5-methyl-2H-pyrazole-3-carboxylic acid (2'-tert-butylsulfamoyl-biphenyl-4-yl)-amide
CAS No.:637318-46-8
Molecular Formula:C₂₉H₃₃N₅O₄S
Molecular Weight:547.678
Hs Code.:

2-(3-aminomethyl-4-methoxy-phenyl)-5-methyl-2<i>H</i>-pyrazole-3-carboxylic acid (2'-<i>tert</i>-butylsulfamoyl-biphenyl-4-yl)-amide

Synonyms:2-(3-aminomethyl-4-methoxy-phenyl)-5-methyl-2H-pyrazole-3-carboxylic acid (2'-tert-butylsulfamoyl-biphenyl-4-yl)-amide

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Chemical Property of 2-(3-aminomethyl-4-methoxy-phenyl)-5-methyl-2H-pyrazole-3-carboxylic acid (2'-tert-butylsulfamoyl-biphenyl-4-yl)-amide

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Technology Process of 2-(3-aminomethyl-4-methoxy-phenyl)-5-methyl-2H-pyrazole-3-carboxylic acid (2'-tert-butylsulfamoyl-biphenyl-4-yl)-amide

There total 12 articles about 2-(3-aminomethyl-4-methoxy-phenyl)-5-methyl-2H-pyrazole-3-carboxylic acid (2'-tert-butylsulfamoyl-biphenyl-4-yl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 637318-41-3
1-(3-azidomethyl-4-methoxyphenyl)-3-methyl-1H-pyrazole-5-(2'-(N-t-butylaminosulfonyl)-[1,1']-biphen-4-yl)carboxamide

: 637318-46-8
2-(3-aminomethyl-4-methoxy-phenyl)-5-methyl-2H-pyrazole-3-carboxylic acid (2'-tert-butylsulfamoyl-biphenyl-4-yl)-amide

Guidance literature:: With tin(ll) chloride; In methanol; at 20 ℃; for 18h;
DOI:10.1021/jm030212h

Reference yield:

: 3403-47-2
3-amino-6-methoxy-benzoic acid

: 637318-46-8
2-(3-aminomethyl-4-methoxy-phenyl)-5-methyl-2H-pyrazole-3-carboxylic acid (2'-tert-butylsulfamoyl-biphenyl-4-yl)-amide

Guidance literature:: Multi-step reaction with 10 steps

1.1: HCl; NaNO₂ / H₂O / 0.5 h / 0 °C

1.2: SnCl₂*2H₂O; HCl / H₂O / 0.25 h / 0 °C

2.1: acetonitrile; H₂O / 3 h / Heating

3.1: N-methylmorpholine / tetrahydrofuran / 0.33 h / 0 °C

4.1: 0.9 g / NaBH₄ / tetrahydrofuran; H₂O / 4 h / 0 - 20 °C

5.1: 0.72 g / Et₃N / CHCl₃ / 18 h / 0 - 20 °C

6.1: NaN₃ / dimethylformamide / 6 h / 60 °C

7.1: 0.17 g / aq. NaOH / ethanol / 4 h / 45 °C

8.1: oxalyl chloride; DMF / CH₂Cl₂; CHCl₃ / 3 h / 0 - 20 °C

9.1: 1.4 g / Et₃N; DMAP / CHCl₃ / 18 h / 0 - 20 °C

10.1: SnCl₂*2H₂O / methanol / 18 h / 20 °C

With 4-methyl-morpholine; hydrogenchloride; dmap; sodium hydroxide; sodium tetrahydroborate; sodium azide; oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; tin(ll) chloride; sodium nitrite; In tetrahydrofuran; methanol; ethanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm030212h

Reference yield:

: 615-79-2
ethyl 2,4-diketopentanoate

: 637318-46-8
2-(3-aminomethyl-4-methoxy-phenyl)-5-methyl-2H-pyrazole-3-carboxylic acid (2'-tert-butylsulfamoyl-biphenyl-4-yl)-amide

Guidance literature:: Multi-step reaction with 10 steps

1: 40 percent / 3A molecular sieves / ethanol / 18 h

2: acetonitrile; H₂O / 3 h / Heating

3: N-methylmorpholine / tetrahydrofuran / 0.33 h / 0 °C

4: 0.9 g / NaBH₄ / tetrahydrofuran; H₂O / 4 h / 0 - 20 °C

5: 0.72 g / Et₃N / CHCl₃ / 18 h / 0 - 20 °C

6: NaN₃ / dimethylformamide / 6 h / 60 °C

7: 0.17 g / aq. NaOH / ethanol / 4 h / 45 °C

8: oxalyl chloride; DMF / CH₂Cl₂; CHCl₃ / 3 h / 0 - 20 °C

9: 1.4 g / Et₃N; DMAP / CHCl₃ / 18 h / 0 - 20 °C

10: SnCl₂*2H₂O / methanol / 18 h / 20 °C

With 4-methyl-morpholine; dmap; sodium hydroxide; sodium tetrahydroborate; sodium azide; oxalyl dichloride; 3 A molecular sieve; triethylamine; N,N-dimethyl-formamide; tin(ll) chloride; In tetrahydrofuran; methanol; ethanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm030212h