Sodium; (Z)-(3R,5S)-7-[2,4-bis-(4-fluoro-phenyl)-6-isopropyl-pyrimidin-5-yl]-6-fluoro-3,5-dihydroxy-hept-6-enoate

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Chemical Name:Sodium; (Z)-(3R,5S)-7-[2,4-bis-(4-fluoro-phenyl)-6-isopropyl-pyrimidin-5-yl]-6-fluoro-3,5-dihydroxy-hept-6-enoate
CAS No.:126706-11-4
Molecular Formula:C₂₆H₂₄F₃N₂O₄*Na
Molecular Weight:508.473
Hs Code.:

Synonyms:Sodium; (Z)-(3R,5S)-7-[2,4-bis-(4-fluoro-phenyl)-6-isopropyl-pyrimidin-5-yl]-6-fluoro-3,5-dihydroxy-hept-6-enoate

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Chemical Property of Sodium; (Z)-(3R,5S)-7-[2,4-bis-(4-fluoro-phenyl)-6-isopropyl-pyrimidin-5-yl]-6-fluoro-3,5-dihydroxy-hept-6-enoate

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Technology Process of Sodium; (Z)-(3R,5S)-7-[2,4-bis-(4-fluoro-phenyl)-6-isopropyl-pyrimidin-5-yl]-6-fluoro-3,5-dihydroxy-hept-6-enoate

There total 10 articles about Sodium; (Z)-(3R,5S)-7-[2,4-bis-(4-fluoro-phenyl)-6-isopropyl-pyrimidin-5-yl]-6-fluoro-3,5-dihydroxy-hept-6-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 126706-21-6
(Z)-(3R,5S)-7-[2,4-Bis-(4-fluoro-phenyl)-6-isopropyl-pyrimidin-5-yl]-6-fluoro-3,5-dihydroxy-hept-6-enoic acid tert-butyl ester

: 126706-11-4
Sodium; (Z)-(3R,5S)-7-[2,4-bis-(4-fluoro-phenyl)-6-isopropyl-pyrimidin-5-yl]-6-fluoro-3,5-dihydroxy-hept-6-enoate

Guidance literature:: With sodium hydroxide; In ethanol; at 20 ℃; for 3h;
DOI:10.1016/S0040-4039(01)93462-8

Reference yield:

: 122253-18-3
[2,4-Bis-(4-fluoro-phenyl)-6-isopropyl-pyrimidin-5-yl]-methanol

: 126706-11-4
Sodium; (Z)-(3R,5S)-7-[2,4-bis-(4-fluoro-phenyl)-6-isopropyl-pyrimidin-5-yl]-6-fluoro-3,5-dihydroxy-hept-6-enoate

Guidance literature:: Multi-step reaction with 8 steps

1: 89 percent / CrO₃, pyridine / CH₂Cl₂ / 0 °C

2: 72 percent / NaH / 1,2-dimethoxy-ethane / 2 h / 20 °C

3: diisobutylaluminium hydride / tetrahydrofuran / 2 h / -10 °C

4: 87 percent / LDA / tetrahydrofuran / 1 h / -70 °C

5: 97 percent / methanol / 16 h / 23 °C

6: 82 percent / LDA / tetrahydrofuran / 1 h / -70 °C

7: 1.) triethylborane/methanol; 2.) sodium borohydride / 1.) THF, -70 deg C, lh; 2.) -70 deg C, 1h

8: 95 percent / 1 M aq sodium hydroxide / ethanol / 3 h / 20 °C

With pyridine; chromium(VI) oxide; methanol; sodium hydroxide; sodium tetrahydroborate; triethyl borane; sodium hydride; diisobutylaluminium hydride; lithium diisopropyl amide; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; ethanol; dichloromethane;
DOI:10.1016/S0040-4039(01)93462-8

Reference yield:

: 126706-12-5
2,4-Bis-(4-fluoro-phenyl)-6-isopropyl-pyrimidine-5-carbaldehyde

: 126706-11-4
Sodium; (Z)-(3R,5S)-7-[2,4-bis-(4-fluoro-phenyl)-6-isopropyl-pyrimidin-5-yl]-6-fluoro-3,5-dihydroxy-hept-6-enoate

Guidance literature:: Multi-step reaction with 7 steps

1: 72 percent / NaH / 1,2-dimethoxy-ethane / 2 h / 20 °C

2: diisobutylaluminium hydride / tetrahydrofuran / 2 h / -10 °C

3: 87 percent / LDA / tetrahydrofuran / 1 h / -70 °C

4: 97 percent / methanol / 16 h / 23 °C

5: 82 percent / LDA / tetrahydrofuran / 1 h / -70 °C

6: 1.) triethylborane/methanol; 2.) sodium borohydride / 1.) THF, -70 deg C, lh; 2.) -70 deg C, 1h

7: 95 percent / 1 M aq sodium hydroxide / ethanol / 3 h / 20 °C

With methanol; sodium hydroxide; sodium tetrahydroborate; triethyl borane; sodium hydride; diisobutylaluminium hydride; lithium diisopropyl amide; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; ethanol;
DOI:10.1016/S0040-4039(01)93462-8