3',5'-dideoxy-N⁶-<2-(4-nitrophenyl)ethoxycarbonyl>-5'-<<2-(4-nitrophenyl)ethoxycarbonyl>amino>adenosine 2'-O-<2-cyanoethyl diisopropylphosphoramidite>

Base Information

• Chemical Name: 3',5'-dideoxy-N⁶-<2-(4-nitrophenyl)ethoxycarbonyl>-5'-<<2-(4-nitrophenyl)ethoxycarbonyl>amino>adenosine 2'-O-<2-cyanoethyl diisopropylphosphoramidite>
• CAS No.: 220867-54-9
• Molecular Formula: C₃₇H₄₅N₁₀O₁₁P
• Molecular Weight: 836.798
• Mol file: 220867-54-9.mol

Synonyms:3',5'-dideoxy-N⁶-<2-(4-nitrophenyl)ethoxycarbonyl>-5'-<<2-(4-nitrophenyl)ethoxycarbonyl>amino>adenosine 2'-O-<2-cyanoethyl diisopropylphosphoramidite>

Chemical Property of 3',5'-dideoxy-N⁶-<2-(4-nitrophenyl)ethoxycarbonyl>-5'-<<2-(4-nitrophenyl)ethoxycarbonyl>amino>adenosine 2'-O-<2-cyanoethyl diisopropylphosphoramidite>

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3',5'-dideoxy-N⁶-<2-(4-nitrophenyl)ethoxycarbonyl>-5'-<<2-(4-nitrophenyl)ethoxycarbonyl>amino>adenosine 2'-O-<2-cyanoethyl diisopropylphosphoramidite>

There total 10 articles about 3',5'-dideoxy-N⁶-<2-(4-nitrophenyl)ethoxycarbonyl>-5'-<<2-(4-nitrophenyl)ethoxycarbonyl>amino>adenosine 2'-O-<2-cyanoethyl diisopropylphosphoramidite> which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite (102691-36-1) + 3',5'-dideoxy-N6-<2-(4-nitrophenyl)ethoxycarbonyl>-5'-<<2-(4-nitrophenyl)ethoxycarbonyl>amino>adenosine (220867-49-2) → 3',5'-dideoxy-N6-<2-(4-nitrophenyl)ethoxycarbonyl>-5'-<<2-(4-nitrophenyl)ethoxycarbonyl>amino>adenosine 2'-O-<2-cyanoethyl diisopropylphosphoramidite> (220867-54-9)

Guidance literature:

With 1H-tetrazole; In dichloromethane; for 18h; Ambient temperature;

DOI:10.1002/(SICI)1522-2675(19990113)82:1<19::AID-HLCA19>3.0.CO;2-G

Reference yield:

1-methyl-3-[2-(4-nitrophenyl)ethoxycarbonyl]imidazolium chloride (88091-70-7) → 3',5'-dideoxy-N6-<2-(4-nitrophenyl)ethoxycarbonyl>-5'-<<2-(4-nitrophenyl)ethoxycarbonyl>amino>adenosine 2'-O-<2-cyanoethyl diisopropylphosphoramidite> (220867-54-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 66 percent / HMDS, NH₄Cl / dioxane / 0.5 h / Heating

2: 76 percent / 1H-tetrazole / CH₂Cl₂ / 18 h / Ambient temperature

With 1H-tetrazole; ammonium chloride; 1,1,1,3,3,3-hexamethyl-disilazane; In 1,4-dioxane; dichloromethane;

DOI:10.1002/(SICI)1522-2675(19990113)82:1<19::AID-HLCA19>3.0.CO;2-G

Reference yield:

2-(4-nitrophenyl)ethoxycarbonyl chloride (88091-68-3) → 3',5'-dideoxy-N6-<2-(4-nitrophenyl)ethoxycarbonyl>-5'-<<2-(4-nitrophenyl)ethoxycarbonyl>amino>adenosine 2'-O-<2-cyanoethyl diisopropylphosphoramidite> (220867-54-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 74 percent / pyridine / CH₂Cl₂ / 2 h / 4 °C

2: 76 percent / 1H-tetrazole / CH₂Cl₂ / 18 h / Ambient temperature

With pyridine; 1H-tetrazole; In dichloromethane;

DOI:10.1002/(SICI)1522-2675(19990113)82:1<19::AID-HLCA19>3.0.CO;2-G

upstream raw materials:

N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite

3',5'-dideoxy-N⁶-<2-(4-nitrophenyl)ethoxycarbonyl>-5'-<<2-(4-nitrophenyl)ethoxycarbonyl>amino>adenosine

1-methyl-3-[2-(4-nitrophenyl)ethoxycarbonyl]imidazolium chloride

2-(4-nitrophenyl)ethoxycarbonyl chloride