(1S,2S)-N-methyl-N,N'-bis(2-pyridylmethyl)-1,2-cyclohexanediamine

Base Information

• Chemical Name: (1S,2S)-N-methyl-N,N'-bis(2-pyridylmethyl)-1,2-cyclohexanediamine
• CAS No.: 1019107-19-7
• Molecular Formula: C₁₉H₂₆N₄
• Molecular Weight: 310.442
• Mol file: 1019107-19-7.mol

Synonyms:(1S,2S)-N-methyl-N,N'-bis(2-pyridylmethyl)-1,2-cyclohexanediamine

Chemical Property of (1S,2S)-N-methyl-N,N'-bis(2-pyridylmethyl)-1,2-cyclohexanediamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1S,2S)-N-methyl-N,N'-bis(2-pyridylmethyl)-1,2-cyclohexanediamine

There total 1 articles about (1S,2S)-N-methyl-N,N'-bis(2-pyridylmethyl)-1,2-cyclohexanediamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + N,N'-bis(pyridin-2-ylmethyl)-(S,S)-1,2-cyclohexanediamine (81748-00-7) → N1,N2?dimethyl?N1,N2?bis(pyridin?2?ylmethyl)cyclohexane?1,2?diamine (515124-12-6) + (1S,2S)-N-methyl-N,N'-bis(2-pyridylmethyl)-1,2-cyclohexanediamine (1019107-19-7)

Guidance literature:

With formic acid; In water; at 90 ℃; for 24h;

DOI:10.1002/ejic.201100785

Reference yield: 53.0%

bromoacetic acid tert-butyl ester (5292-43-3) + (1S,2S)-N-methyl-N,N'-bis(2-pyridylmethyl)-1,2-cyclohexanediamine (1019107-19-7) → C25H36N4O2 (1374659-56-9)

Guidance literature:

With potassium carbonate; In acetonitrile; at 20 ℃; for 3.08333h; Inert atmosphere;

DOI:10.1002/ejic.201100785

Reference yield:

(1S,2S)-N-methyl-N,N'-bis(2-pyridylmethyl)-1,2-cyclohexanediamine (1019107-19-7) → (1S,2S)-N-carboxymethyl-N'-methyl-N,N'-bis(2-pyridylmethyl)-1,2-cyclohexanediamine

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / acetonitrile / 3.08 h / 20 °C / Inert atmosphere

2: trifluoroacetic acid / dichloromethane / 17.5 h / 0 - 20 °C / Inert atmosphere

With potassium carbonate; trifluoroacetic acid; In dichloromethane; acetonitrile;

DOI:10.1002/ejic.201100785

upstream raw materials:

formaldehyd

N,N'-bis(pyridin-2-ylmethyl)-(S,S)-1,2-cyclohexanediamine

Downstream raw materials:

C₂₅H₃₆N₄O₂