4H-Pyrido[1,2-a]pyrimidin-4-one, 9-bromo-7-methyl-2-(4-morpholinyl)-

Base Information

• Chemical Name: 4H-Pyrido[1,2-a]pyrimidin-4-one, 9-bromo-7-methyl-2-(4-morpholinyl)-
• CAS No.: 351002-16-9
• Molecular Formula: C13H14BrN3O2
• Molecular Weight: 324.177
• Hs Code.: 2934999090
• Mol file: 351002-16-9.mol

Synonyms:7-Methyl-2-(4-morpholinyl)-9-bromopyrido[1,2-a]pyrimidin-4-one;9-Bromo-7-methyl-2-(morpholin-4-yl)-4H-pyrido[1,2-a]pyrimidin-4-one;TGX 066;

Chemical Property of 4H-Pyrido[1,2-a]pyrimidin-4-one, 9-bromo-7-methyl-2-(4-morpholinyl)-

Chemical Property:

• Boiling Point: 447.3 °C at 760 mmHg
• PKA: 1.30±0.70(Predicted)
• Flash Point: 224.3 °C
• PSA: 46.84000
• Density: 1.63 g/cm³
• LogP: 1.66700
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

NLT 98% ^*data from raw suppliers

9-Bromo-7-methyl-2-morpholino-4H-pyrido[1,2-a]pyrimidin-4-one 98.0% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4H-Pyrido[1,2-a]pyrimidin-4-one, 9-bromo-7-methyl-2-(4-morpholinyl)-

There total 6 articles about 4H-Pyrido[1,2-a]pyrimidin-4-one, 9-bromo-7-methyl-2-(4-morpholinyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

morpholine (110-91-8,99108-56-2) + 9-bromo-2-hydroxy-7-methyl-4H-pyrido[1,2-a]pyrimidin-4-one hydrochloride (1173900-34-9) → TGX066 (351002-16-9)

Guidance literature:

9-bromo-2-hydroxy-7-methyl-4H-pyrido[1,2-a]pyrimidin-4-one hydrochloride; With triethylamine; In tetrahydrofuran; at 5 ℃; for 0.166667h;

With methanesulfonyl chloride; In tetrahydrofuran; at 5 ℃;

morpholine; In tetrahydrofuran; water; at 20 - 65 ℃;

Reference yield: 90.0%

morpholine (110-91-8,99108-56-2) + 9-bromo-2-hydroxy-7-methyl-4H-pyrido[1,2-a]pyrimidin-4-one (663619-90-7) → TGX066 (351002-16-9)

Guidance literature:

9-bromo-2-hydroxy-7-methyl-4H-pyrido[1,2-a]pyrimidin-4-one; With methanesulfonyl chloride; triethylamine; In dichloromethane; at 20 ℃; Cooling with ice;

morpholine; In dichloromethane; for 24h; Reflux;

DOI:10.1016/j.bmc.2015.03.073

Reference yield:

morpholine (110-91-8,99108-56-2) + C10H9BrN2O4S → TGX066 (351002-16-9)

Guidance literature:

In dichloromethane; for 24h; Reflux;

DOI:10.1021/mp3000309

upstream raw materials:

morpholine

9-bromo-2-hydroxy-7-methyl-4H-pyrido[1,2-a]pyrimidin-4-one

3-bromo-5-methylpyridin-2-amine

9-bromo-2-hydroxy-7-methyl-4H-pyrido[1,2-a]pyrimidin-4-one hydrochloride

Downstream raw materials:

9-(1-hydroxyethyl)-7-methyl-2-morpholino-4H-pyrido[1,2-a]pyrimidin-4-one

C₂₉H₃₈N₄O₄

C₃₉H₅₈N₄O₄

7-methyl-2-(4-morpholinyl)-9-{[(1R)-1-phenylethyl]amino}-4H-pyrido[1,2-a]pyrimidin-4-one

Refernces

• 1、 Liu, Chunjing,Li, Benyi,Mitscher, Lester. "Synthesis of new TGX-221 analogs". . p. 817 - 822. Retrieved 2014/08/18.
• 2、 Tai, Wanyi,Shukla, Ravi S.,Qin, Bin,Li, Benyi,Cheng, Kun. "Development of a peptide-drug conjugate for prostate cancer therapy". scheme or table. p. 901 - 912. Retrieved 2012/06/15.