3-hydroxy-4-(4-isopropylbenzoyl)-1-(6-methylpyridazin-3-yl)-5-(6-(trifluoromethoxy)pyridin-3-yl)-1H-pyrrol-2(5H)-one

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Chemical Name:3-hydroxy-4-(4-isopropylbenzoyl)-1-(6-methylpyridazin-3-yl)-5-(6-(trifluoromethoxy)pyridin-3-yl)-1H-pyrrol-2(5H)-one
CAS No.:1384878-02-7
Molecular Formula:C₂₅H₂₁F₃N₄O₄
Molecular Weight:498.461
Hs Code.:

Synonyms:3-hydroxy-4-(4-isopropylbenzoyl)-1-(6-methylpyridazin-3-yl)-5-(6-(trifluoromethoxy)pyridin-3-yl)-1H-pyrrol-2(5H)-one

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Chemical Property of 3-hydroxy-4-(4-isopropylbenzoyl)-1-(6-methylpyridazin-3-yl)-5-(6-(trifluoromethoxy)pyridin-3-yl)-1H-pyrrol-2(5H)-one

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Technology Process of 3-hydroxy-4-(4-isopropylbenzoyl)-1-(6-methylpyridazin-3-yl)-5-(6-(trifluoromethoxy)pyridin-3-yl)-1H-pyrrol-2(5H)-one

There total 10 articles about 3-hydroxy-4-(4-isopropylbenzoyl)-1-(6-methylpyridazin-3-yl)-5-(6-(trifluoromethoxy)pyridin-3-yl)-1H-pyrrol-2(5H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 18591-87-2,18591-82-7
3-amino-6-methylpyridazine

: 852814-99-4
ethyl 4-[4-(1-methylethyl)phenyl]-2,4-dioxobutanoate

: 1361849-85-5
6-(trifluoromethoxy)nicotinaldehyde

: 1384878-02-7
3-hydroxy-4-(4-isopropylbenzoyl)-1-(6-methylpyridazin-3-yl)-5-(6-(trifluoromethoxy)pyridin-3-yl)-1H-pyrrol-2(5H)-one

Guidance literature:: 3-amino-6-methylpyridazine; 6-(trifluoromethoxy)nicotinaldehyde; acetic acid; In ethanol; at 20 ℃; for 0.25h;

ethyl 4-[4-(1-methylethyl)phenyl]-2,4-dioxobutanoate; In ethanol; for 24h; Reflux;

Reference yield:

: 1221171-70-5
2-chloro-6-(trifluoromethoxy)pyridine

: 1384878-02-7
3-hydroxy-4-(4-isopropylbenzoyl)-1-(6-methylpyridazin-3-yl)-5-(6-(trifluoromethoxy)pyridin-3-yl)-1H-pyrrol-2(5H)-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 2.5 h / -78 °C

1.2: 1 h / 20 °C

2.1: n-butyllithium / hexane; tetrahydrofuran / 2 h / -78 °C / Inert atmosphere

2.3: pH 5

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 16 h / 0 - 20 °C

4.1: ammonium formate / palladium on activated charcoal / methanol / 17 h / 60 °C

5.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 16 h / 20 °C

6.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / -78 °C

7.1: acetic acid / ethanol / 0.25 h / 20 °C

7.2: 24 h / Reflux

With lithium aluminium tetrahydride; n-butyllithium; tetrabutyl ammonium fluoride; ammonium formate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; diisopropylamine; palladium on activated charcoal; acetic acid; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane;

Reference yield:

: 1221172-02-6
2-chloro-6-(trifluoromethoxy)-5-(trimethylsilyl)pyridine

: 1384878-02-7
3-hydroxy-4-(4-isopropylbenzoyl)-1-(6-methylpyridazin-3-yl)-5-(6-(trifluoromethoxy)pyridin-3-yl)-1H-pyrrol-2(5H)-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-butyllithium / hexane; tetrahydrofuran / 2 h / -78 °C / Inert atmosphere

1.3: pH 5

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 16 h / 0 - 20 °C

3.1: ammonium formate / palladium on activated charcoal / methanol / 17 h / 60 °C

4.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 16 h / 20 °C

5.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / -78 °C

6.1: acetic acid / ethanol / 0.25 h / 20 °C

6.2: 24 h / Reflux

With lithium aluminium tetrahydride; n-butyllithium; tetrabutyl ammonium fluoride; ammonium formate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium on activated charcoal; acetic acid; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane;