1221172-02-6

Basic information

• Product Name: 6-chloro-2-(trifluoroMethoxy)-3-(triMethylsilyl)pyridine
• Synonyms: 6-chloro-2-(trifluoroMethoxy)-3-(triMethylsilyl)pyridine
• CAS NO: 1221172-02-6
• Molecular Formula: C₉H₁₁ClF₃NOSi
• Molecular Weight: 269.7234496
• Mol File: 1221172-02-6.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 6-chloro-2-(trifluoroMethoxy)-3-(triMethylsilyl)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-chloro-2-(trifluoroMethoxy)-3-(triMethylsilyl)pyridine(1221172-02-6)
• EPA Substance Registry System: 6-chloro-2-(trifluoroMethoxy)-3-(triMethylsilyl)pyridine(1221172-02-6)

Safety Data

• Hazardous Substances Data: 1221172-02-6(Hazardous Substances Data)

Usage

Description

6-chloro-2-(trifluoromethoxy)-3-(trimethylsilyl)pyridine is a chemical compound featuring a chloro group and a trifluoromethoxy group on a pyridine ring, along with a trimethylsilyl group. 6-chloro-2-(trifluoroMethoxy)-3-(triMethylsilyl)pyridine is known for its role in enhancing the stability and reactivity of molecules in organic synthesis.

Uses

Used in Organic Synthesis:
6-chloro-2-(trifluoromethoxy)-3-(trimethylsilyl)pyridine is used as a reagent for the introduction of a trimethylsilyl group onto a molecule, which can help to increase its stability and/or reactivity.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 6-chloro-2-(trifluoromethoxy)-3-(trimethylsilyl)pyridine is utilized for the development of new drugs, contributing to the advancement of medicinal chemistry.
Used in Agrochemicals:
6-chloro-2-(trifluoromethoxy)-3-(trimethylsilyl)pyridine is employed in the field of agrochemicals for the synthesis of new active ingredients, potentially enhancing the effectiveness of agricultural products.
Used in Material Science:
6-chloro-2-(trifluoroMethoxy)-3-(triMethylsilyl)pyridine has potential applications in material science, where it may contribute to the development of new materials with specific properties.
Used as a Building Block:
6-chloro-2-(trifluoromethoxy)-3-(trimethylsilyl)pyridine serves as a building block in the production of various organic compounds, facilitating the creation of a wide range of chemical products.

Upstream product

• 16879-02-0 6-chloro-2-pyridone 
• 1221171-69-2 2-chloro-6-(trichloromethoxy)pyridine 
• 16879-02-0 6-chloro-2-hydroxypyridine 
• 75-77-4 chloro-trimethyl-silane 
• 1221171-70-5 2-chloro-6-(trifluoromethoxy)pyridine 

Downstream Products

• 1221172-04-8 2-chloro-6-(trifluoromethoxy)nicotinic acid 
• 940895-85-2 6-(trifluoromethoxy)nicotinic acid 
• 1384878-12-9 3-hydroxy-4-(4-isopropylbenzoyl)-1-(6-methylpyridazin-3-yl)-5(R)-(6-(trifluoromethoxy)pyridin-3-yl)-1H-pyrrol-2(5H)-one 
• 1384878-11-8 3-hydroxy-4-(4-isopropylbenzoyl)-1-(6-methylpyridazin-3-yl)-5(S)-(6-(trifluoromethoxy)pyridin-3-yl)-1H-pyrrol-2(5H)-one 
• 1384878-02-7 3-hydroxy-4-(4-isopropylbenzoyl)-1-(6-methylpyridazin-3-yl)-5-(6-(trifluoromethoxy)pyridin-3-yl)-1H-pyrrol-2(5H)-one 
• 135900-33-3 3-amino-6-(trifluoromethoxy)pyridine 
• 1221172-05-9 3-amino-2-chloro-6-(trifluoromethoxy)pyridine 

Relevant articles and documents

2-AMINO-N-PHENYL-NICOTINAMIDES AS NAV1.8 INHIBITORS

Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are inhibitors of Nav1.8 channel activity and may be useful in the treatment, prevention, management, amelioration, control and suppression of diseases mediated by Nav1.8 channel activity. The compounds of the present invention may be useful in the treatment, prevention or management of pain disorders, cough disorders, acute itch disorders, and chronic itch disorders.

Tri- and difluoromethoxylated N-based heterocycles ? Synthesis and insecticidal activity of novel F3CO- and F2HCO-analogues of Imidacloprid and Thiacloprid

The preparation of F3CO- and F2HCO-analogues of Imidacloprid and Thiacloprid and the evaluation of their biological activity have been performed. For this purpose, a first synthetic approach allowed the preparation of a desired F3CO-containing key intermediate. To allow a facile access to the second F2HCO-containing key intermediate, the difluoromethylation of hydroxylated N-based heterocycles has been developed using difluoromethyl triflate (a liquid non-ODS reagent) under air in aqueous conditions and with very short reaction time. The broad diversity of compatible heterocycles includes a large series of substituted hydroxy-pyridines, but also ?pyrazoles, ?pyrazine, ?pyridazine, and ?quinolines. The couplings of both key intermediates with the required 4,5-dihydro-N-nitro-1H-imidazol-2-amine and [N(Z)]-N-2-thiazolidinylidene-cyanamide were successfully achieved using literature conditions. This work enables the preparation of valuable building blocks, which could lead to the discovery of new bioactive entities.

1-(6-MEMBERED AZO-HETEROCYCLIC)-2,5-DIHYDRO-1H-PYRROL-2-ONE DERIVATIVES AS ANTI-HEPATITIS C VIRUS, THE PHARMACEUTICAL COMPOSITION THEREOF AND THEIR THERAPEUTIC USE

The present invention concerns 1-(6-memberedazo-heterocyclic)-2,5-dihydro–1H–pyrrol–2-one compoundsof the following formula (I) or a salt, solvate, tautomer, isotope, enantiomer, diastereoisomer or racemic mixture thereof: the pharmaceutical composition thereof and their therapeutic use as inhibitors of Hepatitis C virus.