(S)-2-tert-Butoxycarbonylamino-6-[3-(4-methyl-pyridin-3-yl)-propionylamino]-hexanoic acid methyl ester

Base Information

Chemical Name:(S)-2-tert-Butoxycarbonylamino-6-[3-(4-methyl-pyridin-3-yl)-propionylamino]-hexanoic acid methyl ester
CAS No.:129483-55-2
Molecular Formula:C₂₁H₃₃N₃O₅
Molecular Weight:407.51
Hs Code.:

Synonyms:(S)-2-tert-Butoxycarbonylamino-6-[3-(4-methyl-pyridin-3-yl)-propionylamino]-hexanoic acid methyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-2-tert-Butoxycarbonylamino-6-[3-(4-methyl-pyridin-3-yl)-propionylamino]-hexanoic acid methyl ester

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Technology Process of (S)-2-tert-Butoxycarbonylamino-6-[3-(4-methyl-pyridin-3-yl)-propionylamino]-hexanoic acid methyl ester

There total 2 articles about (S)-2-tert-Butoxycarbonylamino-6-[3-(4-methyl-pyridin-3-yl)-propionylamino]-hexanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 55757-60-3
N-α-(tert-butoxycarbonyl)-L-lysine methyl ester

: 129483-51-8
3-(4-methyl-pyridin-3-yl)-propionic acid

: 129483-55-2
(S)-2-tert-Butoxycarbonylamino-6-[3-(4-methyl-pyridin-3-yl)-propionylamino]-hexanoic acid methyl ester

Guidance literature:: With diphenyl-phosphinic acid; triethylamine; In N,N-dimethyl-formamide; for 16h; Ambient temperature;
DOI:10.3987/COM-89-S17

Reference yield:

: 5444-01-9
3-cyano-4-methylpyridine

: 129483-55-2
(S)-2-tert-Butoxycarbonylamino-6-[3-(4-methyl-pyridin-3-yl)-propionylamino]-hexanoic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) DIBAL, 2.) 1 N HCl / 1.) CH₂Cl₂/hexane, from -78 deg C, to RT, 2.) 1 h

2: 81 percent / benzene / 5 h / Ambient temperature

3: H₂ / Pd/C / ethanol / 3 h / 50 °C / 1520 Torr

4: KOH, H₂O

5: 83 percent / DPPA, Et₃N / dimethylformamide / 16 h / Ambient temperature

With hydrogenchloride; potassium hydroxide; diphenyl-phosphinic acid; water; hydrogen; diisobutylaluminium hydride; triethylamine; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide; benzene;
DOI:10.3987/COM-89-S17