3-tert-butoxycarbonyl-2-ethylcarbamoylamino-4-(4-fluorophenyl)-5-(4-pyridyl)thiophene

Base Information

• Chemical Name: 3-tert-butoxycarbonyl-2-ethylcarbamoylamino-4-(4-fluorophenyl)-5-(4-pyridyl)thiophene
• CAS No.: 409059-76-3
• Molecular Formula: C₂₃H₂₄FN₃O₃S
• Molecular Weight: 441.526
• Mol file: 409059-76-3.mol

Synonyms:3-tert-butoxycarbonyl-2-ethylcarbamoylamino-4-(4-fluorophenyl)-5-(4-pyridyl)thiophene

Chemical Property of 3-tert-butoxycarbonyl-2-ethylcarbamoylamino-4-(4-fluorophenyl)-5-(4-pyridyl)thiophene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-tert-butoxycarbonyl-2-ethylcarbamoylamino-4-(4-fluorophenyl)-5-(4-pyridyl)thiophene

There total 4 articles about 3-tert-butoxycarbonyl-2-ethylcarbamoylamino-4-(4-fluorophenyl)-5-(4-pyridyl)thiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

bis(trichloromethyl) carbonate (32315-10-9) + ethylamine (75-04-7,85404-22-4) + 2-amino-4-(4-fluoro-phenyl)-5-pyridin-4-yl-thiophene-3-carboxylic acid tert-butyl ester (585525-87-7) → 3-tert-butoxycarbonyl-2-ethylcarbamoylamino-4-(4-fluorophenyl)-5-(4-pyridyl)thiophene (409059-76-3)

Guidance literature:

bis(trichloromethyl) carbonate; 2-amino-4-(4-fluoro-phenyl)-5-pyridin-4-yl-thiophene-3-carboxylic acid tert-butyl ester; With triethylamine; In dichloromethane; at 20 ℃; for 2h;

ethylamine; In dichloromethane; for 1h;

DOI:10.1016/S0968-0896(02)00224-9

Reference yield:

picoline (108-89-4) → 3-tert-butoxycarbonyl-2-ethylcarbamoylamino-4-(4-fluorophenyl)-5-(4-pyridyl)thiophene (409059-76-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 91 percent / lithium bis(trimethylsilyl)amide / tetrahydrofuran / 1 h / 0 °C

2.1: triethylamine; sulfur / ethanol / 72 h / 60 °C

3.1: triethylamine / CH₂Cl₂ / 2 h / 20 °C

3.2: CH₂Cl₂ / 1 h

With sulfur; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; dichloromethane;

DOI:10.1016/S0968-0896(02)00224-9

Reference yield:

1-(4-fluorophenyl)-2-(4-pyridyl)ethanone (6576-05-2) → 3-tert-butoxycarbonyl-2-ethylcarbamoylamino-4-(4-fluorophenyl)-5-(4-pyridyl)thiophene (409059-76-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine; sulfur / ethanol / 72 h / 60 °C

2.1: triethylamine / CH₂Cl₂ / 2 h / 20 °C

2.2: CH₂Cl₂ / 1 h

With sulfur; triethylamine; In ethanol; dichloromethane;

DOI:10.1016/S0968-0896(02)00224-9

upstream raw materials:

bis(trichloromethyl) carbonate

ethylamine

2-amino-4-(4-fluoro-phenyl)-5-pyridin-4-yl-thiophene-3-carboxylic acid tert-butyl ester

picoline

Downstream raw materials:

2-ethylamino-5-(4-fluorophenyl)-6-(4-pyridyl)-4H-thieno[2,3-d][1,3]oxazin-4-one