(S)-1-{[1',2'-dihydro-2'-oxospiro(1,3-dioxane-2,3'-[3H]indol)-5'-yl]sulfonyl}-2-(phenoxymethyl)-pyrrolidine

Base Information

Chemical Name:(S)-1-{[1',2'-dihydro-2'-oxospiro(1,3-dioxane-2,3'-[3H]indol)-5'-yl]sulfonyl}-2-(phenoxymethyl)-pyrrolidine
CAS No.:869223-94-9
Molecular Formula:C₂₂H₂₄N₂O₆S
Molecular Weight:444.508
Hs Code.:

Synonyms:(S)-1-{[1',2'-dihydro-2'-oxospiro(1,3-dioxane-2,3'-[3H]indol)-5'-yl]sulfonyl}-2-(phenoxymethyl)-pyrrolidine

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Chemical Property of (S)-1-{[1',2'-dihydro-2'-oxospiro(1,3-dioxane-2,3'-[3H]indol)-5'-yl]sulfonyl}-2-(phenoxymethyl)-pyrrolidine

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Technology Process of (S)-1-{[1',2'-dihydro-2'-oxospiro(1,3-dioxane-2,3'-[3H]indol)-5'-yl]sulfonyl}-2-(phenoxymethyl)-pyrrolidine

There total 1 articles about (S)-1-{[1',2'-dihydro-2'-oxospiro(1,3-dioxane-2,3'-[3H]indol)-5'-yl]sulfonyl}-2-(phenoxymethyl)-pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 220509-98-8
5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dione

: 504-63-2
trimethyleneglycol

: 869223-94-9
(S)-1-{[1',2'-dihydro-2'-oxospiro(1,3-dioxane-2,3'-[3H]indol)-5'-yl]sulfonyl}-2-(phenoxymethyl)-pyrrolidine

Guidance literature:: With toluene-4-sulfonic acid; In benzene; for 24h; Reflux; Inert atmosphere;
DOI:10.1039/b819024k

Reference yield: 94.0%

: 869223-94-9
(S)-1-{[1',2'-dihydro-2'-oxospiro(1,3-dioxane-2,3'-[3H]indol)-5'-yl]sulfonyl}-2-(phenoxymethyl)-pyrrolidine

: 112905-95-0
1-(chloromethyl)cyclohexanecarbonitrile

: 1202497-88-8
1-([5'-([(2S)-2-(phenoxymethyl)pyrrolidin-1-yl]sulfonyl)-2'-oxospiro[1,3-dioxane-2,3'-indol]-1'(2'H)-yl]methyl)cyclohexanecarbonitrile

Guidance literature:: (S)-1-{[1',2'-dihydro-2'-oxospiro(1,3-dioxane-2,3'-[3H]indol)-5'-yl]sulfonyl}-2-(phenoxymethyl)-pyrrolidine; With potassium tert-butylate; In dimethyl sulfoxide; for 0.333333h; Inert atmosphere;

1-(chloromethyl)cyclohexanecarbonitrile; In dimethyl sulfoxide; at 185 ℃; for 21h; Inert atmosphere;
DOI:10.1016/j.bmc.2009.09.036

Reference yield: 84.3%

: 869223-94-9
(S)-1-{[1',2'-dihydro-2'-oxospiro(1,3-dioxane-2,3'-[3H]indol)-5'-yl]sulfonyl}-2-(phenoxymethyl)-pyrrolidine

: 131221-78-8
3-chloro-2,2-dimethylpropanenitrile

: 869223-97-2
2,2-dimethyl-3-[2'-oxo-5'-{[(2S)-2-(phenoxymethyl)pyrrolidin-1-yl]sulfonyl}spiro[1,3-dioxane-2,3'-indol]-1'(2'H)-yl]propanenitrile

Guidance literature:: (S)-1-{[1',2'-dihydro-2'-oxospiro(1,3-dioxane-2,3'-[3H]indol)-5'-yl]sulfonyl}-2-(phenoxymethyl)-pyrrolidine; With potassium tert-butylate; In dimethyl sulfoxide; at 20 ℃; for 0.166667h;

3-chloro-2,2-dimethylpropanenitrile; at 20 - 132 ℃; for 30.5h;