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(3R,5S,6S)-3-allyl-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-1-((S)-1-(5-methylpyridin-2-yl)propyl)piperidin-2-one is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

1619258-07-9

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1619258-07-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1619258-07-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,6,1,9,2,5 and 8 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1619258-07:
(9*1)+(8*6)+(7*1)+(6*9)+(5*2)+(4*5)+(3*8)+(2*0)+(1*7)=179
179 % 10 = 9
So 1619258-07-9 is a valid CAS Registry Number.

1619258-07-9Relevant academic research and scientific papers

Discovery of potent and simplified piperidinone-based inhibitors of the MDM2-p53 interaction

Yu, Ming,Wang, Yingcai,Zhu, Jiang,Bartberger, Michael D.,Canon, Jude,Chen, Ada,Chow, David,Eksterowicz, John,Fox, Brian,Fu, Jiasheng,Gribble, Michael,Huang, Xin,Li, Zhihong,Liu, Jiwen,Lo, Mei-Chu,McMinn, Dustin,Oliner, Jonathan D.,Osgood, Tao,Rew, Yosup,Saiki, Anne Y.,Shaffer, Paul,Yan, Xuelei,Ye, Qiuping,Yu, Dongyin,Zhao, Xiaoning,Zhou, Jing,Olson, Steven H.,Medina, Julio C.,Sun, Daqing

, p. 894 - 899 (2014/09/17)

Continued optimization of the N-substituent in the piperidinone series provided potent piperidinone-pyridine inhibitors 6, 7, 14, and 15 with improved pharmacokinetic properties in rats. Reducing structure complexity of the N-alkyl substituent led to the discovery of 23, a potent and simplified inhibitor of MDM2. Compound 23 exhibits excellent pharmacokinetic properties and substantial in vivo antitumor activity in the SJSA-1 osteosarcoma xenograft mouse model.

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