ethyl-5-(3-(4-benzyloxy-3-methylphenyl)pentan-3-yl)-1-methylpyrrole-2-carboxylate

Base Information

• Chemical Name: ethyl-5-(3-(4-benzyloxy-3-methylphenyl)pentan-3-yl)-1-methylpyrrole-2-carboxylate
• CAS No.: 1447711-34-3
• Molecular Formula: C₂₇H₃₃NO₃
• Molecular Weight: 419.564
• Mol file: 1447711-34-3.mol

Synonyms:ethyl-5-(3-(4-benzyloxy-3-methylphenyl)pentan-3-yl)-1-methylpyrrole-2-carboxylate

Chemical Property of ethyl-5-(3-(4-benzyloxy-3-methylphenyl)pentan-3-yl)-1-methylpyrrole-2-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl-5-(3-(4-benzyloxy-3-methylphenyl)pentan-3-yl)-1-methylpyrrole-2-carboxylate

There total 6 articles about ethyl-5-(3-(4-benzyloxy-3-methylphenyl)pentan-3-yl)-1-methylpyrrole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.4%

ethyl 5-(3-(4-(benzyloxy)-3-methylphenyl)pentan-3-yl)-1H-pyrrole-2-carboxylate (1447711-33-2) + methyl iodide (74-88-4) → ethyl-5-(3-(4-benzyloxy-3-methylphenyl)pentan-3-yl)-1-methylpyrrole-2-carboxylate (1447711-34-3)

Guidance literature:

ethyl 5-(3-(4-(benzyloxy)-3-methylphenyl)pentan-3-yl)-1H-pyrrole-2-carboxylate; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.5h;

methyl iodide; In N,N-dimethyl-formamide; at 25 ℃; for 2h;

DOI:10.1016/j.ejmech.2013.09.015

Reference yield:

4-hydroxy-3-methylbenzoic acid (499-76-3) → ethyl-5-(3-(4-benzyloxy-3-methylphenyl)pentan-3-yl)-1-methylpyrrole-2-carboxylate (1447711-34-3)

Guidance literature:

Multi-step reaction with 5 steps

1.1: sulfuric acid / 6 h / Reflux

2.1: potassium carbonate; potassium iodide / 6 h / Reflux

3.1: diethyl ether / 2 h / 0 - 30 °C

4.1: boron trifluoride diethyl etherate / dichloromethane / 1 h / 0 - 25 °C

5.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

5.2: 2 h / 25 °C

With sulfuric acid; boron trifluoride diethyl etherate; sodium hydride; potassium carbonate; potassium iodide; In diethyl ether; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2013.09.015

Reference yield:

ethyl 1H-pyrrole-2-carboxylate (2199-43-1) → ethyl-5-(3-(4-benzyloxy-3-methylphenyl)pentan-3-yl)-1-methylpyrrole-2-carboxylate (1447711-34-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: boron trifluoride diethyl etherate / dichloromethane / 1 h / 0 - 25 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

2.2: 2 h / 25 °C

With boron trifluoride diethyl etherate; sodium hydride; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2013.09.015

upstream raw materials:

4-hydroxy-3-methylbenzoic acid

ethyl 1H-pyrrole-2-carboxylate

ethyl 5-(3-(4-(benzyloxy)-3-methylphenyl)pentan-3-yl)-1H-pyrrole-2-carboxylate

methyl iodide

Downstream raw materials:

(S)-2-(5-(3-(4-(3,3-dimethyl-2-oxobutoxy)-3-methylphenyl)pentan-3-yl)-1-methylpyrrole-2-carboxamido)succinic acid

2-(5-(3-(4-(2-hydroxy-3,3-dimethylbutoxy)-3-methylphenyl)pentan-3-yl)-1-methylpyrrole-2-carboxamido)acetic acid

3-(5-(3-(4-(2-hydroxy-3,3-dimethylbutoxy)-3-methylphenyl)pentan-3-yl)-1-methylpyrrole-2-carboxamido)propanoic acid

(S)-2-(5-(3-(4-(2-hydroxy-3,3-dimethylbutoxy)-3-methylphenyl)pentan-3-yl)-1-methylpyrrole-2-carboxamido)propanoic acid