ethyl 5-(3-(4-(benzyloxy)-3-methylphenyl)pentan-3-yl)-1H-pyrrole-2-carboxylate

Base Information

• Chemical Name: ethyl 5-(3-(4-(benzyloxy)-3-methylphenyl)pentan-3-yl)-1H-pyrrole-2-carboxylate
• CAS No.: 1447711-33-2
• Molecular Formula: C₂₆H₃₁NO₃
• Molecular Weight: 405.537
• Mol file: 1447711-33-2.mol

Synonyms:ethyl 5-(3-(4-(benzyloxy)-3-methylphenyl)pentan-3-yl)-1H-pyrrole-2-carboxylate

Chemical Property of ethyl 5-(3-(4-(benzyloxy)-3-methylphenyl)pentan-3-yl)-1H-pyrrole-2-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 5-(3-(4-(benzyloxy)-3-methylphenyl)pentan-3-yl)-1H-pyrrole-2-carboxylate

There total 5 articles about ethyl 5-(3-(4-(benzyloxy)-3-methylphenyl)pentan-3-yl)-1H-pyrrole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

3-(4-(benzyloxy)-3-methylphenyl)pentan-3-ol (1445854-54-5) + ethyl 1H-pyrrole-2-carboxylate (2199-43-1) → ethyl 5-(3-(4-(benzyloxy)-3-methylphenyl)pentan-3-yl)-1H-pyrrole-2-carboxylate (1447711-33-2)

Guidance literature:

With boron trifluoride diethyl etherate; In dichloromethane; at 0 - 25 ℃; for 1h;

DOI:10.1016/j.ejmech.2013.09.015

Reference yield:

methyl 4-hydroxy-3-methylbenzoate (42113-13-3) → ethyl 5-(3-(4-(benzyloxy)-3-methylphenyl)pentan-3-yl)-1H-pyrrole-2-carboxylate (1447711-33-2)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate; potassium iodide / 6 h / Reflux

2: diethyl ether / 2 h / 0 - 30 °C

3: boron trifluoride diethyl etherate / dichloromethane / 1 h / 0 - 25 °C

With boron trifluoride diethyl etherate; potassium carbonate; potassium iodide; In diethyl ether; dichloromethane;

DOI:10.1016/j.ejmech.2013.09.015

Reference yield:

4-hydroxy-3-methylbenzoic acid (499-76-3) → ethyl 5-(3-(4-(benzyloxy)-3-methylphenyl)pentan-3-yl)-1H-pyrrole-2-carboxylate (1447711-33-2)

Guidance literature:

Multi-step reaction with 4 steps

1: sulfuric acid / 6 h / Reflux

2: potassium carbonate; potassium iodide / 6 h / Reflux

3: diethyl ether / 2 h / 0 - 30 °C

4: boron trifluoride diethyl etherate / dichloromethane / 1 h / 0 - 25 °C

With sulfuric acid; boron trifluoride diethyl etherate; potassium carbonate; potassium iodide; In diethyl ether; dichloromethane;

DOI:10.1016/j.ejmech.2013.09.015

upstream raw materials:

4-hydroxy-3-methylbenzoic acid

3-(4-(benzyloxy)-3-methylphenyl)pentan-3-ol

ethyl 1H-pyrrole-2-carboxylate

methyl 4-(benzyloxy)-3-methylbenzoate

Downstream raw materials:

ethyl-5-(3-(4-benzyloxy-3-methylphenyl)pentan-3-yl)-1-methylpyrrole-2-carboxylate

ethyl 5-(3-(4-(benzyloxy)-3-methylphenyl)pentan-3-yl)-1-ethyl-1H-pyrrole-2-carboxylate