4-(5-bromo-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoic acid tert-butyl ester hydrochloride

Base Information

Chemical Name:4-(5-bromo-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoic acid tert-butyl ester hydrochloride
CAS No.:1598386-35-6
Molecular Formula:C₂₁H₂₃BrN₂O₃*ClH
Molecular Weight:467.79
Hs Code.:

Synonyms:4-(5-bromo-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoic acid tert-butyl ester hydrochloride

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Chemical Property of 4-(5-bromo-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoic acid tert-butyl ester hydrochloride

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Technology Process of 4-(5-bromo-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoic acid tert-butyl ester hydrochloride

There total 5 articles about 4-(5-bromo-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoic acid tert-butyl ester hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.7%

: 1430563-97-5
5-bromo-1-((4-(tert-butoxycarbonyl)phenyl)carbamoyl)-3,4-dihydroisoquinolin-2(1H)-carboxylic acid tert-butyl ester

: 1598386-35-6
4-(5-bromo-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoic acid tert-butyl ester hydrochloride

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; 1,4-dioxane; at 0 - 20 ℃; for 1.5h;

Reference yield:

: 1430563-90-8
5-bromo-2-(methoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid

: 1598386-35-6
4-(5-bromo-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoic acid tert-butyl ester hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide / water; 1,4-dioxane; ethanol / 48 h / 90 °C

1.2: 5 h / 20 °C

2.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

3.1: hydrogenchloride / tetrahydrofuran; 1,4-dioxane / 1.5 h / 0 - 20 °C

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 1109230-24-1
methyl 2-(2-bromophenyl)ethylcarbamate

: 1598386-35-6
4-(5-bromo-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoic acid tert-butyl ester hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetic acid; sulfuric acid / 0 - 20 °C

2.1: sodium hydroxide / water; 1,4-dioxane; ethanol / 48 h / 90 °C

2.2: 5 h / 20 °C

3.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

4.1: hydrogenchloride / tetrahydrofuran; 1,4-dioxane / 1.5 h / 0 - 20 °C

With hydrogenchloride; sulfuric acid; acetic acid; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide;