tert-butyl 5-bromo-1-((4-(tert-butoxycarbonyl)phenyl)carbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

Base Information

Chemical Name:tert-butyl 5-bromo-1-((4-(tert-butoxycarbonyl)phenyl)carbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate
CAS No.:1430563-97-5
Molecular Formula:C₂₆H₃₁BrN₂O₅
Molecular Weight:531.447
Hs Code.:
Mol file:1430563-97-5.mol

Synonyms:tert-butyl 5-bromo-1-((4-(tert-butoxycarbonyl)phenyl)carbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

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Chemical Property of tert-butyl 5-bromo-1-((4-(tert-butoxycarbonyl)phenyl)carbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

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Technology Process of tert-butyl 5-bromo-1-((4-(tert-butoxycarbonyl)phenyl)carbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

There total 8 articles about tert-butyl 5-bromo-1-((4-(tert-butoxycarbonyl)phenyl)carbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1430563-91-9
5-bromo-2-(tert-butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid

: 18144-47-3
tert-butyl 4-aminobenzoate

: 1430563-97-5
5-bromo-1-((4-(tert-butoxycarbonyl)phenyl)carbamoyl)-3,4-dihydroisoquinolin-2(1H)-carboxylic acid tert-butyl ester

Guidance literature:: With pyridine; trichlorophosphate; at -15 ℃; for 2h;

Reference yield:

: 65185-58-2
2-(2-bromophenyl)ethanamine

: 1430563-97-5
5-bromo-1-((4-(tert-butoxycarbonyl)phenyl)carbamoyl)-3,4-dihydroisoquinolin-2(1H)-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: pyridine / dichloromethane / 1 h / 0 °C

2: acetic acid; sulfuric acid / 0 - 20 °C

3: sodium hydroxide / ethanol; 1,4-dioxane / 0.5 h / 150 °C / Microwave irradiation

4: sodium hydroxide / 1,4-dioxane / 2 h

5: trichlorophosphate; pyridine / 2 h / -15 °C

With pyridine; sulfuric acid; acetic acid; sodium hydroxide; trichlorophosphate; In 1,4-dioxane; ethanol; dichloromethane;

Reference yield:

: 1430563-90-8
5-bromo-2-(methoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid

: 1430563-97-5
5-bromo-1-((4-(tert-butoxycarbonyl)phenyl)carbamoyl)-3,4-dihydroisoquinolin-2(1H)-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide / ethanol; 1,4-dioxane / 0.5 h / 150 °C / Microwave irradiation

2: sodium hydroxide / 1,4-dioxane / 2 h

3: trichlorophosphate; pyridine / 2 h / -15 °C

With pyridine; sodium hydroxide; trichlorophosphate; In 1,4-dioxane; ethanol;