(2S,3S,6S)-2-(2-Benzenesulfonyl-1,1-dimethyl-ethyl)-6-[(2R,3R)-2,3-bis-(tert-butyl-dimethyl-silanyloxy)-butyl]-4-[2-(tert-butyl-diphenyl-silanyloxy)-eth-(E)-ylidene]-2-methoxy-tetrahydro-pyran-3-ol

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Chemical Name:(2S,3S,6S)-2-(2-Benzenesulfonyl-1,1-dimethyl-ethyl)-6-[(2R,3R)-2,3-bis-(tert-butyl-dimethyl-silanyloxy)-butyl]-4-[2-(tert-butyl-diphenyl-silanyloxy)-eth-(E)-ylidene]-2-methoxy-tetrahydro-pyran-3-ol
CAS No.:380579-02-2
Molecular Formula:C₅₀H₈₀O₈SSi₃
Molecular Weight:925.503
Hs Code.:

(2S,3S,6S)-2-(2-Benzenesulfonyl-1,1-dimethyl-ethyl)-6-[(2R,3R)-2,3-bis-(tert-butyl-dimethyl-silanyloxy)-butyl]-4-[2-(tert-butyl-diphenyl-silanyloxy)-eth-(E)-ylidene]-2-methoxy-tetrahydro-pyran-3-ol

Synonyms:(2S,3S,6S)-2-(2-Benzenesulfonyl-1,1-dimethyl-ethyl)-6-[(2R,3R)-2,3-bis-(tert-butyl-dimethyl-silanyloxy)-butyl]-4-[2-(tert-butyl-diphenyl-silanyloxy)-eth-(E)-ylidene]-2-methoxy-tetrahydro-pyran-3-ol

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Chemical Property of (2S,3S,6S)-2-(2-Benzenesulfonyl-1,1-dimethyl-ethyl)-6-[(2R,3R)-2,3-bis-(tert-butyl-dimethyl-silanyloxy)-butyl]-4-[2-(tert-butyl-diphenyl-silanyloxy)-eth-(E)-ylidene]-2-methoxy-tetrahydro-pyran-3-ol

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Technology Process of (2S,3S,6S)-2-(2-Benzenesulfonyl-1,1-dimethyl-ethyl)-6-[(2R,3R)-2,3-bis-(tert-butyl-dimethyl-silanyloxy)-butyl]-4-[2-(tert-butyl-diphenyl-silanyloxy)-eth-(E)-ylidene]-2-methoxy-tetrahydro-pyran-3-ol

There total 14 articles about (2S,3S,6S)-2-(2-Benzenesulfonyl-1,1-dimethyl-ethyl)-6-[(2R,3R)-2,3-bis-(tert-butyl-dimethyl-silanyloxy)-butyl]-4-[2-(tert-butyl-diphenyl-silanyloxy)-eth-(E)-ylidene]-2-methoxy-tetrahydro-pyran-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 380579-07-7
(2S,6S)-2-(2-Benzenesulfonyl-1,1-dimethyl-ethyl)-6-[(2R,3R)-2,3-bis-(tert-butyl-dimethyl-silanyloxy)-butyl]-4-[2-(tert-butyl-diphenyl-silanyloxy)-eth-(E)-ylidene]-2-methoxy-dihydro-pyran-3-one

: 380579-02-2
(2S,3S,6S)-2-(2-Benzenesulfonyl-1,1-dimethyl-ethyl)-6-[(2R,3R)-2,3-bis-(tert-butyl-dimethyl-silanyloxy)-butyl]-4-[2-(tert-butyl-diphenyl-silanyloxy)-eth-(E)-ylidene]-2-methoxy-tetrahydro-pyran-3-ol

Guidance literature:: With sodium tetrahydroborate; cerium(III) chloride; In methanol; at -78 - 0 ℃; for 1.08333h;
DOI:10.1021/ol016800b

Reference yield:

: 38434-99-0
3-Benzenesulfonyl-2,2-dimethyl-propionic acid methyl ester

: 380579-02-2
(2S,3S,6S)-2-(2-Benzenesulfonyl-1,1-dimethyl-ethyl)-6-[(2R,3R)-2,3-bis-(tert-butyl-dimethyl-silanyloxy)-butyl]-4-[2-(tert-butyl-diphenyl-silanyloxy)-eth-(E)-ylidene]-2-methoxy-tetrahydro-pyran-3-ol

Guidance literature:: Multi-step reaction with 8 steps

1.1: 65 percent / n-BuLi / tetrahydrofuran; hexane / 4 h / -78 - 20 °C

2.1: LiCl; i-Pr₂NEt / acetonitrile / 16 h / 20 °C

3.1: H₂ / Pd(OH)2/C / methanol / 2 h / 20 °C

4.1: 84 percent / camphorsulfonic acid / benzene / 2 h / Heating

5.1: dimethyldioxirane; 4 Angstroem molecular sieves / acetone; methanol / 0.2 h / 0 °C

5.2: PPTS; 4 Angstroem molecular sieves / acetone / 0.17 h / 20 °C

6.1: pyridinium dichromate / dimethylformamide / 12 h / 20 °C

7.1: n-BuLi / hexane; tetrahydrofuran / 0.5 h / -78 - 20 °C

8.1: 80 percent / CeCl₃*7H₂O; NaBH₄ / methanol / 1.08 h / -78 - 0 °C

With sodium tetrahydroborate; dipyridinium dichromate; n-butyllithium; cerium(III) chloride; 4 A molecular sieve; camphor-10-sulfonic acid; hydrogen; 3,3-dimethyldioxirane; N-ethyl-N,N-diisopropylamine; lithium chloride; palladium dihydroxide; In tetrahydrofuran; methanol; hexane; N,N-dimethyl-formamide; acetone; acetonitrile; benzene; 2.1: Horner-Wadsworth-Emmons reaction / 8.1: Luche reduction;
DOI:10.1021/ol016800b

Reference yield:

: 38435-02-8
2,2-dimethyl-3-(phenylsulfonyl)propanoic acid

: 380579-02-2
(2S,3S,6S)-2-(2-Benzenesulfonyl-1,1-dimethyl-ethyl)-6-[(2R,3R)-2,3-bis-(tert-butyl-dimethyl-silanyloxy)-butyl]-4-[2-(tert-butyl-diphenyl-silanyloxy)-eth-(E)-ylidene]-2-methoxy-tetrahydro-pyran-3-ol

Guidance literature:: Multi-step reaction with 9 steps

1.1: K₂CO₃ / dimethylformamide / 12 h / 20 °C

2.1: 65 percent / n-BuLi / tetrahydrofuran; hexane / 4 h / -78 - 20 °C

3.1: LiCl; i-Pr₂NEt / acetonitrile / 16 h / 20 °C

4.1: H₂ / Pd(OH)2/C / methanol / 2 h / 20 °C

5.1: 84 percent / camphorsulfonic acid / benzene / 2 h / Heating

6.1: dimethyldioxirane; 4 Angstroem molecular sieves / acetone; methanol / 0.2 h / 0 °C

6.2: PPTS; 4 Angstroem molecular sieves / acetone / 0.17 h / 20 °C

7.1: pyridinium dichromate / dimethylformamide / 12 h / 20 °C

8.1: n-BuLi / hexane; tetrahydrofuran / 0.5 h / -78 - 20 °C

9.1: 80 percent / CeCl₃*7H₂O; NaBH₄ / methanol / 1.08 h / -78 - 0 °C

With sodium tetrahydroborate; dipyridinium dichromate; n-butyllithium; cerium(III) chloride; 4 A molecular sieve; camphor-10-sulfonic acid; hydrogen; 3,3-dimethyldioxirane; potassium carbonate; N-ethyl-N,N-diisopropylamine; lithium chloride; palladium dihydroxide; In tetrahydrofuran; methanol; hexane; N,N-dimethyl-formamide; acetone; acetonitrile; benzene; 3.1: Horner-Wadsworth-Emmons reaction / 9.1: Luche reduction;
DOI:10.1021/ol016800b