38434-99-0Relevant articles and documents
Concise formal synthesis of the bryostatin southern hemisphere (C17-C27)
Voight, Eric A.,Roethle, Paul A.,Burke, Steven D.
, p. 4534 - 4537 (2007/10/03)
An efficient synthesis of Hale and co-workers' C17-C27 bryostatin southern hemisphere intermediate has been accomplished in six steps and 33% overall yield from (R)-2-(benzyloxy)propanal. The synthesis features a one-pot DIBALH/HWE ester homologation as w
A short synthetic pathway to a fully-functionalized southern hemisphere of the antitumor macrolide bryostatin 1.
Hale,Frigerio,Manaviazar
, p. 3791 - 3794 (2007/10/03)
[reaction--see text] An 18-step asymmetric synthesis of the bryostatin 1 "southern hemisphere" fragment (1) has been developed. Key steps include an aldol reaction between 6 and 7 and a dehydration to establish the (E)-exocyclic alkene in 2 and a stereose