C₂₅H₂₈FNO

Base Information

• Chemical Name: C₂₅H₂₈FNO
• CAS No.: 1419184-37-4
• Molecular Formula: C₂₅H₂₈FNO
• Molecular Weight: 377.502
• Mol file: 1419184-37-4.mol

Synonyms:C₂₅H₂₈FNO

Chemical Property of C₂₅H₂₈FNO

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of C₂₅H₂₈FNO

There total 3 articles about C₂₅H₂₈FNO which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

C26H30FNO (1419184-36-3) → C25H28FNO (1419184-37-4)

Guidance literature:

With pyridine hydrochloride; In melt; at 210 ℃; for 12h; Inert atmosphere; Schlenk technique;

DOI:10.1021/om300832q

Reference yield:

2'-Fluoroacetophenone (445-27-2) → C25H28FNO (1419184-37-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 18 h / 120 °C / Inert atmosphere; Schlenk technique

2.1: potassium tert-butylate / tetrahydrofuran / 12 h / 20 °C / Inert atmosphere; Schlenk technique

2.2: 36 h / 20 °C / Inert atmosphere; Schlenk technique

2.3: 2 h / 130 °C / Inert atmosphere; Schlenk technique

3.1: pyridine hydrochloride / melt / 12 h / 210 °C / Inert atmosphere; Schlenk technique

With potassium tert-butylate; pyridine hydrochloride; In tetrahydrofuran; melt;

DOI:10.1021/om300832q

Reference yield:

(E)-3-(N,N-dimethylamino)-1-(2'-fluorophenyl)prop-2-en-1-one (138716-19-5) → C25H28FNO (1419184-37-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium tert-butylate / tetrahydrofuran / 12 h / 20 °C / Inert atmosphere; Schlenk technique

1.2: 36 h / 20 °C / Inert atmosphere; Schlenk technique

1.3: 2 h / 130 °C / Inert atmosphere; Schlenk technique

2.1: pyridine hydrochloride / melt / 12 h / 210 °C / Inert atmosphere; Schlenk technique

With potassium tert-butylate; pyridine hydrochloride; In tetrahydrofuran; melt;

DOI:10.1021/om300832q

upstream raw materials:

2'-Fluoroacetophenone

(E)-3-(N,N-dimethylamino)-1-(2'-fluorophenyl)prop-2-en-1-one

C₂₆H₃₀FNO

Downstream raw materials:

C₃₉H₄₀FNOTi