(S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(2-iodophenyl)-2-methylpropanoic acid

Base Information

Chemical Name:(S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(2-iodophenyl)-2-methylpropanoic acid
CAS No.:1364707-56-1
Molecular Formula:C₂₅H₂₂INO₄
Molecular Weight:527.358
Hs Code.:

Synonyms:(S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(2-iodophenyl)-2-methylpropanoic acid

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Chemical Property of (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(2-iodophenyl)-2-methylpropanoic acid

Chemical Property:

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Technology Process of (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(2-iodophenyl)-2-methylpropanoic acid

There total 1 articles about (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(2-iodophenyl)-2-methylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 1212223-78-3
(S)-2-amino-3-(2-iodophenyl)-2-methylpropanoic acid

: 28920-43-6
(fluorenylmethoxy)carbonyl chloride

: 1364707-56-1
(S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(2-iodophenyl)-2-methylpropanoic acid

Guidance literature:: (S)-2-amino-3-(2-iodophenyl)-2-methylpropanoic acid; With chloro-trimethyl-silane; In dichloromethane; for 6h; Inert atmosphere; Reflux;

(fluorenylmethoxy)carbonyl chloride; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 25 ℃; for 30h; Inert atmosphere;
DOI:10.1021/jo202105v

Reference yield:

: aminomethyl-terminated Tentagel resin

: 35661-39-3,136132-75-7
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

: 1364705-24-7
(S)-2-((tert-butoxycarbonyl)amino)-3-(3-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propanoic acid

: 1364707-56-1
(S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(2-iodophenyl)-2-methylpropanoic acid

: C₄₀H₅₆BClIN₆O₉Pol

Guidance literature:: aminomethyl-terminated Tentagel resin; (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(2-iodophenyl)-2-methylpropanoic acid; With 1-hydroxy-7-aza-benzotriazole; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 1.5h; Inert atmosphere; solid phase reaction;

With piperidine; In N,N-dimethyl-formamide; at 20 ℃; for 0.333333h; Inert atmosphere;

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine; (S)-2-((tert-butoxycarbonyl)amino)-3-(3-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propanoic acid; Further stages;
DOI:10.1021/jo202105v