1-(2-methoxyl-5-chlorophenyl)-3-{1-[1-(t-butyloxycarbonyl)-1H-pyrrolo[2,3-b]pyridin-3-ylmethyl]-1H-indol-4-yl}urea

Base Information

Chemical Name:1-(2-methoxyl-5-chlorophenyl)-3-{1-[1-(t-butyloxycarbonyl)-1H-pyrrolo[2,3-b]pyridin-3-ylmethyl]-1H-indol-4-yl}urea
CAS No.:1268390-81-3
Molecular Formula:C₂₉H₂₈ClN₅O₄
Molecular Weight:546.025
Hs Code.:

Synonyms:1-(2-methoxyl-5-chlorophenyl)-3-{1-[1-(t-butyloxycarbonyl)-1H-pyrrolo[2,3-b]pyridin-3-ylmethyl]-1H-indol-4-yl}urea

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Chemical Property of 1-(2-methoxyl-5-chlorophenyl)-3-{1-[1-(t-butyloxycarbonyl)-1H-pyrrolo[2,3-b]pyridin-3-ylmethyl]-1H-indol-4-yl}urea

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Technology Process of 1-(2-methoxyl-5-chlorophenyl)-3-{1-[1-(t-butyloxycarbonyl)-1H-pyrrolo[2,3-b]pyridin-3-ylmethyl]-1H-indol-4-yl}urea

There total 15 articles about 1-(2-methoxyl-5-chlorophenyl)-3-{1-[1-(t-butyloxycarbonyl)-1H-pyrrolo[2,3-b]pyridin-3-ylmethyl]-1H-indol-4-yl}urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1268390-80-2
3-[(4-amino-1H-indol-1-yl)methyl]-1-(t-butyloxycarbonyl)-1H-pyrrolo[2,3-b]pyridine

: 55440-54-5
5-chloro-2-methoxyphenyl isocyanate

: 1268390-81-3
1-(2-methoxyl-5-chlorophenyl)-3-{1-[1-(t-butyloxycarbonyl)-1H-pyrrolo[2,3-b]pyridin-3-ylmethyl]-1H-indol-4-yl}urea

Guidance literature:: In toluene;

Reference yield:

: 271-63-6
7-Azaindole

: 1268390-81-3
1-(2-methoxyl-5-chlorophenyl)-3-{1-[1-(t-butyloxycarbonyl)-1H-pyrrolo[2,3-b]pyridin-3-ylmethyl]-1H-indol-4-yl}urea

Guidance literature:: Multi-step reaction with 7 steps

1: isopropyl alcohol; water / 20 °C / Reflux

2: triethylamine / dmap / dichloromethane / 20 °C

3: isobutyl chloroformate / toluene / Inert atmosphere

4: sodium hydride / tetrahydrofuran / 4 h

5: triethylamine / dmap / dichloromethane

6: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 2 h

7: toluene

With hydrogen; sodium hydride; triethylamine; isobutyl chloroformate; dmap; palladium 10% on activated carbon; In tetrahydrofuran; dichloromethane; water; isopropyl alcohol; toluene;

Reference yield:

: 144657-68-1
tert-butyl 3-(chloromethyl)-1H-pyrrolo[2,3-b]pyridine-1-carboxylate

: 1268390-81-3
1-(2-methoxyl-5-chlorophenyl)-3-{1-[1-(t-butyloxycarbonyl)-1H-pyrrolo[2,3-b]pyridin-3-ylmethyl]-1H-indol-4-yl}urea

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydride / tetrahydrofuran / 4 h

2: triethylamine / dmap / dichloromethane

3: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 2 h

4: toluene

With hydrogen; sodium hydride; triethylamine; dmap; palladium 10% on activated carbon; In tetrahydrofuran; dichloromethane; toluene;