2,5-Dichlorobenzophenone

Base Information

• Chemical Name: 2,5-Dichlorobenzophenone
• CAS No.: 16611-67-9
• Molecular Formula: C13H8Cl2O
• Molecular Weight: 251.112
• Hs Code.: 2914700090
• European Community (EC) Number: 605-427-1
• DSSTox Substance ID: DTXSID30332482
• Nikkaji Number: J82.526C
• Wikidata: Q72465535
• Mol file: 16611-67-9.mol

Synonyms:2,5-Dichlorobenzophenone;16611-67-9;(2,5-dichlorophenyl)(phenyl)methanone;(2,5-dichlorophenyl)-phenylmethanone;methanone, (2,5-dichlorophenyl)phenyl-;MFCD00079746;SCHEMBL230930;DTXSID30332482;(2,5-dichlorophenyl)phenylmethanone;(2,5-dichlorophenyl)-phenyl-methanone;AKOS009338708;PS-7466;SY016942;CS-0156571;FT-0637385;EN300-130793;Z385417018;150347-09-4

Chemical Property of 2,5-Dichlorobenzophenone

Chemical Property:

• Vapor Pressure: 1.15E-05mmHg at 25°C
• Melting Point: 87-88 °C
• Refractive Index: 1.603
• Boiling Point: 369.9 °C at 760 mmHg
• Flash Point: 156.4 °C
• PSA: 17.07000
• Density: 1.311 g/cm³
• LogP: 4.22440
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 4.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 249.9952203
• Heavy Atom Count: 16
• Complexity: 248

Purity/Quality:

99% ^*data from raw suppliers

2,5-Dichlorobenzophenone ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C(=O)C2=C(C=CC(=C2)Cl)Cl

Technology Process of 2,5-Dichlorobenzophenone

There total 15 articles about 2,5-Dichlorobenzophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

para-dichlorobenzene (106-46-7,84348-21-0) + benzoyl chloride (98-88-4) → (2,5-dichlorophenyl)(phenyl)methanone (16611-67-9)

Guidance literature:

With sodium hydroxide; aluminium trichloride; In water; toluene;

Reference yield: 97.0%

C15H21Cl2MgN + benzoyl chloride (98-88-4) → (2,5-dichlorophenyl)(phenyl)methanone (16611-67-9)

Guidance literature:

C₁₅H₂₁Cl₂MgN; With zinc(II) chloride; In tetrahydrofuran; at 0 ℃; for 0.166667h; Inert atmosphere;

benzoyl chloride; With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; at 25 ℃; for 3h; Inert atmosphere;

DOI:10.1002/adsc.201300185

Reference yield: 78.4%

(5-chloro-2-hydroxyphenyl)phenylmethanone (85-19-8) → (2,5-dichlorophenyl)(phenyl)methanone (16611-67-9)

Guidance literature:

With phosphorus pentachloride; Heating;

DOI:10.1023/B:JOCC.0000044093.61028.70

upstream raw materials:

para-dichlorobenzene

benzoyl chloride

benzoyl triflate

4-chloro-2-(α,α-dichlorobenzyl)phenyl phosphochloridate

Downstream raw materials:

5-chloro-2-phenylselenobenzophenone

C₁₄H₁₂Cl₂N₄*ClH

medazepam

N-[2-Chloro-9-phenyl-9H-10λ⁴-selenoxanthen-(10E)-ylidene]-benzenesulfonamide