((1R),(2R),(3S))-3-((1R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-2-(4-fluorophenyl)cyclopentanecarboxaldehyde

Base Information

Chemical Name:((1R),(2R),(3S))-3-((1R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-2-(4-fluorophenyl)cyclopentanecarboxaldehyde
CAS No.:405512-89-2
Molecular Formula:C₂₂H₁₉F₇O₂
Molecular Weight:448.38
Hs Code.:

Synonyms:((1R),(2R),(3S))-3-((1R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-2-(4-fluorophenyl)cyclopentanecarboxaldehyde

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Chemical Property of ((1R),(2R),(3S))-3-((1R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-2-(4-fluorophenyl)cyclopentanecarboxaldehyde

Chemical Property:

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Technology Process of ((1R),(2R),(3S))-3-((1R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-2-(4-fluorophenyl)cyclopentanecarboxaldehyde

There total 14 articles about ((1R),(2R),(3S))-3-((1R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-2-(4-fluorophenyl)cyclopentanecarboxaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 190266-45-6
[(1R,2R,3S)-3-{(R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy}-2-(4-fluorophenyl)cyclopentyl]methanol

: 405512-89-2
((1R),(2R),(3S))-3-((1R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-2-(4-fluorophenyl)cyclopentanecarboxaldehyde

Guidance literature:: With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -70 ℃; for 1.25h;

Reference yield:

: 190266-45-6
[(1R,2R,3S)-3-{(R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy}-2-(4-fluorophenyl)cyclopentyl]methanol

: 79-37-8
oxalyl dichloride

: 405512-89-2
((1R),(2R),(3S))-3-((1R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-2-(4-fluorophenyl)cyclopentanecarboxaldehyde

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; dimethyl sulfoxide;

Reference yield:

: 3859-41-4
1,3-cyclopentadione

: 405512-89-2
((1R),(2R),(3S))-3-((1R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-2-(4-fluorophenyl)cyclopentanecarboxaldehyde

Guidance literature:: Multi-step reaction with 10 steps

1.1: potassium phosphate; johnphos / palladium diacetate / tetrahydrofuran / 12 h / 100 °C

2.1: disodium hydrogenphosphate / acetonitrile

2.2: 1.5 h / 65 °C

2.3: 0.5 h / pH < 8

3.1: 5% palladium over charcoal / ISOPROPYLAMIDE

3.2: 60 °C / 517.16 Torr

4.1: (R)-methyl oxazaborolidine; dimethylsulfide borane complex / toluene / 2.5 h / -20 °C

4.3: 20 °C

5.1: tetrahydrofuran; toluene / 0.75 h / -48 °C

5.2: 2.5 h / -25 °C

6.1: sulfuric acid / water / 3 h / 20 °C / Heating / reflux

7.1: tetrafluoroboric acid / n-heptane; dichloromethane / 23 h / -8 °C

8.1: n-heptane / 1 h / 30 - 50 °C

9.1: borane-THF / tetrahydrofuran; toluene / 1 h / 0 - 75 °C

10.1: oxalyl dichloride; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.05 h / -70 - 20 °C / Cooling with acetone-dry ice

With potassium phosphate; disodium hydrogenphosphate; borane-THF; oxalyl dichloride; (R)-methyl oxazaborolidine; dimethylsulfide borane complex; sulfuric acid; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; johnphos; palladium diacetate; tetrafluoroboric acid; 5% palladium over charcoal; In tetrahydrofuran; n-heptane; dichloromethane; ISOPROPYLAMIDE; water; toluene; acetonitrile;